ArticleJournal of pediatric surgery2020
Evaluation of the diagnostic biopsy approach for children with hepatoblastoma: A report from the children's oncology group AHEP 0731 liver tumor committee.
Article in Journal of pediatric surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Trial
- Pediatric Personalized Deep Learning Models for Segmentation of Hepatoblastoma at CT and MRI.Radiology. Imaging cancer · 2026Article
- International Society of Paediatric Surgical Oncology (IPSO) Minimally Invasive Surgery (MIS) Guidelines.Ecancermedicalscience · 2026Article
- The Role of IR in Pediatric Liver Cancer.Seminars in interventional radiology · 2025Review
- Hepatoblastoma.Nature reviews. Disease primers · 2025Review
- Intratumoral Heterogeneity and Immune Microenvironment in Hepatoblastoma Revealed by Single-Cell RNA Sequencing.Journal of cellular and molecular medicine · 2025Article
- The role of the minimally invasive surgery in the management of paediatric liver tumours.Ecancermedicalscience · 2025Article
- The role of minimally invasive surgery for diagnosis and staging in paediatric surgical oncology.Ecancermedicalscience · 2025Article
- Management of undifferentiated embryonal sarcoma of the liver: A Pediatric Surgical Oncology Research Collaborative study.Pediatric blood & cancer · 2024Article
- Percutaneous core needle biopsy of neuroblastoma in the pediatric population: what have we learned in the last decade.Pediatric surgery international · 2024Article
- Aggressive Pursuit of No Evidence of Disease Status in Hepatoblastoma Improves Survival: An Observational Study.Journal of pediatric surgery · 2023Observational
- Pediatric and Young Adult Image-Guided Percutaneous Bone Biopsy-A New Standard of Care?Annals of surgical oncology · 2023Article
- The morbidity of open tumor biopsy for intraabdominal neoplasms in pediatric patients.Pediatric surgery international · 2021Article
- A narrative review of the challenges and countermeasures in hepatoblastoma management during COVID-19 epidemic.Translational pediatrics · 2020Review
- Liver biopsy for hepatoblastoma: a single institution's experience.Pediatric surgery international · 2020Article
- Outcomes of children with hepatoblastoma who underwent liver resection at a tertiary hospital in China: a retrospective analysis.BMC pediatrics · 2020Article
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Authors and funding
15 authors.
Funding
Abstract
backgroundThe histopathological assessment of pediatric liver tumors at presentation is critical to establish a diagnosis, guide treatment, and collect appropriate research samples. The purpose of this study was to evaluate complications associated with different approaches to liver biopsy for newly diagnosed hepatoblastoma.
methodsChildren with hepatoblastoma were enrolled on Children's Oncology Group study AHEP0731 (September 2009-March 2012). This analysis evaluated the study cohort of initially unresectable patients who therefore underwent a biopsy procedure at diagnosis. The primary endpoint was clinically significant postbiopsy hemorrhage, defined as requiring red blood cell transfusion.
resultsWe identified 121 children who underwent open (n = 76, 63%), laparoscopic (n = 17, 14%), or percutaneous (n = 28, 23%) liver biopsies. All biopsy procedures yielded adequate tissue for diagnosis. Postbiopsy hemorrhage requiring transfusion occurred after 26% (n = 31) of biopsies. Need for blood product transfusion most frequently occurred following open (n = 27/76, 36%) and laparoscopic (n = 4/17, 24%) biopsies, compared with percutaneous (n = 0/28, 0%) biopsies (p < 0.01).
conclusionsPretreatment biopsy of pediatric liver tumors via a percutaneous approach yielded the lowest frequency of clinically significant hemorrhage requiring transfusion, without evidence of sacrificing diagnostic accuracy. LEVEL OF EVIDENCE: Level I.
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