Evidence map›Paper›PMID 31126684›Full record

ReviewJournal of pediatric surgery2020

Biobanking for necrotizing enterocolitis: Needs and standards.

Hala Chaaban, Troy A Markel, Jennifer Canvasser, Misty Good

Abstract readReview
In one paragraph

Review in Journal of pediatric surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Necrotizing Enterocolitis: What's New and What's Next?International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hala ChaabanDepartment of Pediatrics, Section of Neonatal-Perinatal Medicine, University of Oklahoma, Oklahoma City, OK, USA.
Troy A MarkelDepartment of Surgery, Section of Pediatric Surgery, The Indiana University School of Medicine, Indianapolis, IN, USA.
Jennifer CanvasserNEC Society, Davis, CA, USA.
Misty GoodDepartment of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: mistygood@wustl.edu.

Funding

Modulation of the Intestinal Immune Response in Necrotizing EnterocolitisR01DK118568 · NIDDK · WASHINGTON UNIVERSITY · PI GOOD, MISTY L · 2018 to 2022
$1.8M
Mesenchymal Stromal Cells Modulate Intestinal Mesenteric Endothelium Via Hydrogen SulfideK08DK113226 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI MARKEL, TROY A · 2018 to 2021
$603k
Novel Anti-Inflammatory Properties of Breast Milk in Necrotizing EnterocolitisK08DK101608 · NIDDK · WASHINGTON UNIVERSITY · PI GOOD, MISTY L · 2014 to 2017
$584k
The Role of Extracellular Histones and Neutrophil Extracellular traps in Necrotizing EnterocolitisK08GM127308 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CHAABAN, HALA · 2017 to 2019
$275k
Aryl hydrocarbon receptor signaling in the pathogenesis of necrotizing enterocolitisR03DK111473 · NIDDK · WASHINGTON UNIVERSITY · PI GOOD, MISTY L · 2017 to 2018
$153k
NIDDK NIH HHS K08 DK101608NIDDK NIH HHS K08 DK113226NIDDK NIH HHS R01 DK118568NIDDK NIH HHS R03 DK111473NIGMS NIH HHS K08 GM127308
6 · The paper itself

Abstract

backgroundNecrotizing enterocolitis (NEC) is a devastating gastrointestinal disease that primarily affects premature infants. Despite medical advances, mortality and morbidity from NEC are still unacceptably high. This is partly because of the lack of specific biomarkers and therapies for this disease. Availability of high-quality biological samples and the associated data from premature infants are key to advance our understanding of NEC, and for biomarker discovery and drug development. To that end, the NEC Society Biorepository was established with the goal of promoting studies in human infants through sharing specialized biospecimen and data procurement for NEC research.

objectiveIn this review, we will discuss the required infrastructure for biobanks, discuss the importance of informatics management, and emphasize the logistical requirements for sharing specimens. Finally, we will discuss the mechanism for how tissues and material will be shared between the institutions.

conclusionWe have developed a state-of-the-art biobank for human infants to advance the field of NEC research. With the NEC Society Biorepository, we seek to facilitate and accelerate the basic and translational studies on NEC to provide hope to the infants afflicted with NEC and their families. STUDY TYPE: Review article, level V.

Indexed as

Biomedical ResearchEnterocolitis, NecrotizingBiomarkersHumansInfantInfant, NewbornInfant, PrematureInfant, Premature, DiseasesInformaticsReference StandardsSpecimen HandlingTissue BanksBiomarkersBarcodeBiobankBiomarkerBiorepositoryProcurementSamples

Identifiers

PMID31126684
PMCPMC6842670

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.