ArticleJournal of neuroengineering and rehabilitation2019
Large-scale changes in cortical dynamics triggered by repetitive somatosensory electrical stimulation.
Article in Journal of neuroengineering and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Dynamic electrophysiological changes in abnormal brain cavities post-ischemic stroke.Frontiers in neuroscience · 2025Article
- Cortical processing during robot and functional electrical stimulation.Frontiers in systems neuroscience · 2023Article
- Movement-dependent electrical stimulation for volitional strengthening of cortical connections in behaving monkeys.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Non-invasive electrical stimulation of peripheral nerves for the management of tremor.Journal of the neurological sciences · 2022Review
- Epidural cerebellar stimulation drives widespread neural synchrony in the intact and stroke perilesional cortex.Journal of neuroengineering and rehabilitation · 2021Article
- The effects of mechanical tactile stimulation on corticospinal excitability and motor function depend on pin protrusion patterns.Scientific reports · 2019Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRepetitive somatosensory electrical stimulation (SES) of forelimb peripheral nerves is a promising therapy; studies have shown that SES can improve motor function in stroke subjects with chronic deficits. However, little is known about how SES can directly modulate neural dynamics. Past studies using SES have primarily used noninvasive methods in human subjects. Here we used electrophysiological recordings from the rodent primary motor cortex (M1) to assess how SES affects neural dynamics at the level of single neurons as well as at the level of mesoscale dynamics.
methodsWe performed acute extracellular recordings in 7 intact adult Long Evans rats under ketamine-xylazine anesthesia while they received transcutaneous SES. We recorded single unit spiking and local field potentials (LFP) in the M1 contralateral to the stimulated arm. We then compared neural firing rate, spike-field coherence (SFC), and power spectral density (PSD) before and after stimulation.
resultsFollowing SES, the firing rate of a majority of neurons changed significantly from their respective baseline values. There was, however, a diversity of responses; some neurons increased while others decreased their firing rates. Interestingly, SFC, a measure of how a neuron's firing is coupled to mesoscale oscillatory dynamics, increased specifically in the δ-band, also known as the low frequency band (0.3- 4 Hz). This increase appeared to be driven by a change in the phase-locking of broad-spiking, putative pyramidal neurons. These changes in the low frequency range occurred without a significant change in the overall PSD.
conclusionsRepetitive SES significantly and persistently altered the local cortical dynamics of M1 neurons, changing both firing rates as well as the SFC magnitude in the δ-band. Thus, SES altered the neural firing and coupling to ongoing mesoscale dynamics. Our study provides evidence that SES can directly modulate cortical dynamics.
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