Evidence map›Paper›PMID 31126316›Full record

ReviewJournal of hematology & oncology2019

Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia.

Yan Liu, Zhiheng Cheng, Yifan Pang, Longzhen Cui, Tingting Qian, Liang Quan, Hongyou Zhao, Jinlong Shi, Xiaoyan Ke, Lin Fu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of hematology & oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 2 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 2 syntheses or guidelines pooled it, 284 citations in OpenAlex.

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  18. Diagnostic value of circular RNAs as promising hematological biomarkers in acute myeloid leukemia: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025
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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Yan LiuDepartment of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Zhiheng ChengDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Yifan PangDepartment of Medicine, William Beaumont Hospital, Royal Oak, MI, 48073, USA.
Longzhen CuiTranslational Medicine Center, Huaihe Hospital of Henan University, Kaifeng, 475000, China.
Tingting QianDepartment of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Liang QuanDepartment of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Hongyou ZhaoDepartment of Laser Medicine, Chinese PLA General Hospital, Beijing, 100853, China.
Jinlong ShiDepartment of Biomedical Engineering, Chinese PLA General Hospital, Beijing, 100853, China.
Xiaoyan KeDepartment of Hematology and Lymphoma Research Center, Peking University Third Hospital, Beijing, 100191, China.
Lin FuDepartment of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China. fulin022@126.com.ORCID 0000-0002-2416-7572
Henan University Huaihe Hospital and Huaihe Clinical Institute · CNChinese PLA General Hospital · CNSecond Affiliated Hospital of Guangzhou Medical University · CNBeaumont Hospital, Royal Oak · USPeking University · CNUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is a malignant tumor of the immature myeloid hematopoietic cells in the bone marrow (BM). It is a highly heterogeneous disease, with rising morbidity and mortality in older patients. Although researches over the past decades have improved our understanding of AML, its pathogenesis has not yet been fully elucidated. Long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) are three noncoding RNA (ncRNA) molecules that regulate DNA transcription and translation. With the development of RNA-Seq technology, more and more ncRNAs that are closely related to AML leukemogenesis have been discovered. Numerous studies have found that these ncRNAs play an important role in leukemia cell proliferation, differentiation, and apoptosis. Some may potentially be used as prognostic biomarkers. In this systematic review, we briefly described the characteristics and molecular functions of three groups of ncRNAs, including lncRNAs, miRNAs, and circRNAs, and discussed their relationships with AML in detail.

Indexed as

AnimalsGene Expression Regulation, LeukemicHumansLeukemia, Myeloid, AcuteMicroRNAsRNA, CircularRNA, Long NoncodingMicroRNAsRNA, CircularRNA, Long NoncodingAcute myeloid leukemiacircRNALong noncoding RNAmicroRNA

Identifiers

PMID31126316
PMCPMC6534901
OpenAlexW2947379685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.