ArticleMalaria journal2019
High Plasmodium infection and multiple insecticide resistance in a major malaria vector Anopheles coluzzii from Sahel of Niger Republic.
Article in Malaria journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Effectiveness of indoor residual spraying on malaria control: a systematic review and meta-analysis.Infectious diseases of poverty · 2022Pooled it
- Four-year monitoring of the malaria vector Anopheles funestus in central-west Cameroon reveals an escalation of pyrethroid resistance combined with high malaria transmission.BMC infectious diseases · 2026Article
- First detection and entomological characterisation of invasive malaria vector Anopheles stephensi in sympatry with other vectors in Gayi Southern Niger Republic.Scientific reports · 2025Article
- Cost of the national malaria control program and cost-effectiveness of indoor residual spraying and insecticide-treated bed net interventions in two districts of Madagascar.Cost effectiveness and resource allocation : C/E · 2024Article
- Exploring the molecular mechanisms of increased intensity of pyrethroid resistance in Central African population of a major malaria vectorEvolutionary applications · 2024Article
- First identification of Microsporidia MB in Anopheles coluzzii from Zinder City, Niger.Parasites & vectors · 2024Article
- Molecular drivers of insecticide resistance in the Sahelo-Sudanian populations of a major malaria vector Anopheles coluzzii.BMC biology · 2023Article
- The duplicated P450s CYP6P9a/b drive carbamates and pyrethroids cross-resistance in the major African malaria vector Anopheles funestus.PLoS genetics · 2023Article
- Countrywide insecticide resistance monitoring and first report of the presence of the L1014S knock down resistance in Niger, West Africa.Malaria journal · 2022Article
- DDT Resistance inGenes · 2022Article
- Article
- Current Status of Insecticide Susceptibility in the Principal Malaria Vector,Journal of arthropod-borne diseases · 2021Article
- From Global to Local-New Insights into Features of Pyrethroid Detoxification in Vector Mosquitoes.Insects · 2021Review
- Biochemical Mechanism of Insecticide Resistance in Malaria Vector,Iranian journal of public health · 2021Article
- First Report of Target Site Insensitivity in Pyrethroid ResistantJournal of arthropod-borne diseases · 2020Article
- High insecticide resistance in the major malaria vector Anopheles coluzzii in Chad Republic.Infectious diseases of poverty · 2019Article
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundInformation on insecticide resistance and the mechanisms driving it in the major malaria vectors is grossly lacking in Niger Republic, thus hindering control efforts. To facilitate evidence-based malaria control, the role of Anopheles coluzzii population from southern Niger, in malaria transmission, its insecticides resistance profile and the molecular mechanisms driving the resistance were characterized.
methodsBlood fed female Anopheles gambiae sensu lato resting indoor were collected at Tessaoua, Niger. Source of blood was established using PCR and infection with Plasmodium determined using TaqMan assay. Resistance profile was established with the major public health insecticides, and resistance intensity determined with deltamethrin. Synergist assays were conducted with piperonyl butoxide and diethyl maleate. Presence of L1014F and L1014S knockdown resistance (kdr) mutations in the voltage-gated sodium channel (VGSC) was investigated using TaqMan genotyping, and strength of selection pressure acting on the Anopheles populations determined by assessing the genetic diversity of a fragment spanning exon-20 of the VGSC from alive and dead females.
resultsHigh human blood index (96%) and high Plasmodium falciparum infection (~ 13%) was observed in the An. coluzzii population. Also, a single mosquito was found infected with Plasmodium vivax. High pyrethroid and organochloride resistance was observed with mortalities of less than 20% for deltamethrin, permethrin, α-cypermethrin, and DDT. A high LD
conclusionHigh pyrethroid resistance highlight the challenges to the effectiveness of the pyrethroids-based ITNs and indoor residual spraying (IRS) against An. coluzzii in Niger. The pyrethroids-synergists LLINs and organophosphate-based IRS maybe the alternatives for malaria control in southern Niger.
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