Observational studyBMC pulmonary medicine2019
Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH): a pragmatic real-life longitudinal study of difficult asthma in the clinic.
Observational study in BMC pulmonary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Clinical phenotypes of difficult-to-treat and mild asthma defined by cluster analysis.Respiratory research · 2026Article
- Circulating microRNAs as Potential Diagnostic Tools for Asthma and for Indicating Severe Asthma Risk.International journal of molecular sciences · 2025Article
- Article
- Circulating Nitrite in Severe Asthma: Just Another Biomarker or Novel Treatment Target?Allergy · 2025Article
- Patient-centred composite scores as tools for assessment of response to biological therapy for paediatric and adult severe asthma.The European respiratory journal · 2025Article
- Cytotoxic CD4Med (New York, N.Y.) · 2023Article
- The RNA binding proteinsFrontiers in cell and developmental biology · 2023Article
- Measurement of Exhaled Volatile Organic Compounds as a Biomarker for Personalised Medicine: Assessment of Short-Term Repeatability in Severe Asthma.Journal of personalized medicine · 2022Article
- Nontypeable Haemophilus influenzae infection of pulmonary macrophages drives neutrophilic inflammation in severe asthma.Allergy · 2022Article
- Multimorbidity in Difficult Asthma: The Need for Personalised and Non-Pharmacological Approaches to Address a Difficult Breathing Syndrome.Journal of personalized medicine · 2022Review
- Validation and further insight into the International Severe Asthma Registry (ISAR) eosinophil gradient algorithm in the Wessex AsThma CoHort of difficult asthma (WATCH) using historical blood eosinophil counts and induced sputum.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Article
- The Detrimental Clinical Associations of Anxiety and Depression with Difficult Asthma Outcomes.Journal of personalized medicine · 2022Article
- Article
- Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in Asthma.Antioxidants (Basel, Switzerland) · 2021Article
- Circulating miRNAs-A potential tool to identify severe asthma risk?Clinical and translational allergy · 2021Article
- Patient perceived barriers to exercise and their clinical associations in difficult asthma.Asthma research and practice · 2020Article
Corrections and comments
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Authors and funding
22 authors.
Funding
Abstract
backgroundAsthma is now widely recognised to be a heterogeneous disease. The last two decades have seen the identification of a number of biological targets and development of various novel therapies. Despite this, asthma still represents a significant health and economic burden worldwide. Why some individuals should continue to suffer remains unclear.
methodsThe Wessex Asthma Cohort of Difficult Asthma (WATCH) is an ongoing 'real-life', prospective study of patients in the University Hospital Southampton Foundation Trust (UHSFT) Difficult Asthma service. Research data capture is aligned with the extensive clinical characterisation required of a commissioned National Health Service (NHS) Specialist Centre for Severe Asthma. Data acquisition includes detailed clinical, health and disease-related questionnaires, anthropometry, allergy and lung function testing, radiological imaging (in a small subset) and collection of biological samples (blood, urine and sputum). Prospective data are captured in parallel to clinical follow up appointments, with data entered into a bespoke database. DISCUSSION: The pragmatic ongoing nature of the WATCH study allows comprehensive assessment of the real world clinical spectrum seen in a Specialist Asthma Centre and allows a longitudinal perspective of deeply phenotyped patients. It is anticipated that the WATCH cohort would act as a vehicle for potential collaborative asthma studies and will build upon our understanding of mechanisms underlying difficult asthma.
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