Evidence map›Paper›PMID 31126091›Full record

ArticleCancers2019

Novel Thienopyrimidine Derivative, RP-010, Induces β-Catenin Fragmentation and Is Efficacious against Prostate Cancer Cells.

Haneen Amawi, Noor Hussein, Sai H S Boddu, Chandrabose Karthikeyan, Frederick E Williams, Charles R Ashby, Dayanidhi Raman, Piyush Trivedi, Amit K Tiwari

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Haneen AmawiDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA. haneen.amawi@yu.edu.jo.
Noor HusseinDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA. noor.hussein@rockets.utoledo.edu.
Sai H S BodduCollege of Pharmacy and Health Sciences, Ajman University, P.O. Box. 346 Ajman, UAE. s.boddu@ajman.ac.ae.
Chandrabose KarthikeyanSchool of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Gandhi Nagar, Bhopal 462036, India. karthinobel@gmail.com.
Frederick E WilliamsDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA. frederick.williams2@utoledo.edu.
Charles R AshbyDepartment of Pharmaceutical Sciences, College of Pharmacy, St. John's University, Queens, NY 11432, USA. cnsratdoc@optonline.net.
Dayanidhi RamanDepartment of Cancer Biology, College of Medicine, University of Toledo, Toledo, OH 43614 USA. dayanidhi.raman@utoledo.edu.
Piyush TrivediSchool of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Gandhi Nagar, Bhopal 462036, India. piyushtrivedi304@gmail.com.
Amit K TiwariDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA. amit.tiwari@utoledo.edu.ORCID 0000-0002-7427-7155
University of Toledo · USRajiv Gandhi Technical University · INAjman University · AESt. John's University · USYarmouk University · JO

Funding

University of Toledo F110760
6 · The paper itself

Abstract

Thienopyrimidines containing a thiophene ring fused to pyrimidine are reported to have a wide-spectrum of anticancer efficacy in vitro. Here, we report for the first time that thieno[3,2-

Indexed as

apoptosismetastasisprostate cancerRP-010thienopyrimidinesWnt/β-catenin

Identifiers

PMID31126091
PMCPMC6563099
OpenAlexW2946355199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.