Preparation and in Vitro Evaluation of New Composite Mesh Functionalized with Cationic Antimicrobial Peptide.

Pengbi Liu, Nanliang Chen, Jinhua Jiang, Xuejun Wen

Open access · goldAbstract read

In one paragraph

Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

1.3field-weighted citation impact, top 20% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 12 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Pengbi LiuCollege of Textiles, Donghua University, Shanghai 201620, China. 1135009@mail.dhu.edu.cn.ORCID 0000-0002-1230-5034

Nanliang ChenCollege of Textiles, Donghua University, Shanghai 201620, China. nlch@dhu.edu.cn.

Jinhua JiangCollege of Textiles, Donghua University, Shanghai 201620, China. jiangjinhua@dhu.edu.cn.ORCID 0000-0001-8848-0990

Xuejun WenDepartment of Chemical and Life Science Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA. xwen@vcu.edu.

Donghua University · CNVirginia Commonwealth University · US

Funding

China Scholarship Council 201706630077Donghua University the international visiting programNational Key R&D Program of China 2016YFB0303300

6 · The paper itself

Abstract

Infection caused by bacteria in hernia repair site is a severe complication, and patients have to undergo a second surgery to remove the infected prosthesis. In this study, we developed a composite biological safe mesh with antibacterial activity. The composite mesh is composed of large pore polypropylene (PP) mesh, poly-caprolactone (PCL) and antimicrobial peptide (PEP-1), which we synthesized in our lab. Fourier transformed infrared (FTIR) spectroscopy was utilized to analyze the functional groups. The surface morphology, in vitro release characters, mechanical properties, antibacterial activities, and in vitro cytotoxicity of modified mesh were evaluated. Results showed that PEP-1 was loaded in fibers successfully and could diffuse from nanofibers to inhibit bacteria (

Indexed as

antibacterialantimicrobial peptidecytotoxicityelectrospinninghernia repairin vitro releasemechanical propertiessurgical mesh

Identifiers

PMID31126063

DOI10.3390/ma12101676

PMCPMC6566986

OpenAlexW2946186431

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.