Evidence map›Paper›PMID 31126011›Full record

ArticleInternational journal of molecular sciences2019

Core-Fucosylated Tetra-Antennary

Harmin Herrera, Tinslee Dilday, Allison Uber, Danielle Scott, Joelle N Zambrano, Mengjun Wang, Peggi M Angel, Anand S Mehta, Richard R Drake, Elizabeth G Hill and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

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  11. ReliableMolecules (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Harmin HerreraGraduate School of Biomedical Sciences and Professional Studies, Microbiology and Immunology Graduate Program, Drexel University College of Medicine, Philadelphia, PA 19129, USA. hh435@drexel.edu.ORCID 0000-0003-3587-0041
Tinslee DildayDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA. dilday@musc.edu.
Allison UberDepartment of Pediatrics, Division of Hematology/Oncology, Medical University of South Carolina, Charleston, SC 29425, USA. uber@musc.edu.
Danielle ScottDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA. scottd@musc.edu.ORCID 0000-0003-2461-9812
Joelle N ZambranoDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA. zambrano@musc.edu.
Mengjun WangDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA. wangm@musc.edu.
Peggi M AngelDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA. angelp@musc.edu.ORCID 0000-0002-4436-555X
Anand S MehtaDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA. mehtaa@musc.edu.
Richard R DrakeDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA. draker@musc.edu.
Elizabeth G HillDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA. hille@musc.edu.
Elizabeth S YehDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA. esyeh@iu.edu.
Medical University of South Carolina · USDrexel University · US

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
MUSC Minority Student Development ProgramR25GM072643 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ERGUL, ADVIYE, RINKER, JENNIFER ANNE · 2005 to 2023
$5.8M
MUSC Post-Baccalaureate Research Education ProgramR25GM113278 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DELEON-PENNELL, KRISTINE Y, PENROD-MARTIN, RACHEL · 2015 to 2024
$2.7M
NCATS NIH HHS UL1 TR001450NIGMS NIH HHS R25 GM072643NIGMS NIH HHS R25 GM113278
6 · The paper itself

Abstract

(1) Glycoproteins account for ~80% of proteins located at the cell surface and in the extracellular matrix. A growing body of evidence indicates that α-L-fucose protein modifications contribute to breast cancer progression and metastatic disease. (2) Using a combination of techniques, including matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) based in cell and on tissue imaging and glycan sequencing using exoglycosidase analysis coupled to hydrophilic interaction ultra-high performance liquid chromatography (HILIC UPLC), we establish that a core-fucosylated tetra-antennary glycan containing a single

Indexed as

Amino SugarsAnimalsBreast NeoplasmsCell Line, TumorChromatography, High Pressure LiquidFemaleFucoseGlycoproteinsGlycosylationHumansLymph NodesMice, Inbred BALB CNeoplasm MetastasisPolysaccharidesSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSurvival AnalysisAmino SugarsFucoseGlycoproteinsN-acetyllactosaminepolylactosaminePolysaccharidesbreast cancercore-fucoseN-acetyllactosamineN-glycan

Identifiers

PMID31126011
PMCPMC6566954
OpenAlexW2944992247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.