ReviewInternational journal for parasitology. Drugs and drug resistance2019
Refugia and anthelmintic resistance: Concepts and challenges.
Review in International journal for parasitology. Drugs and drug resistance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 138 citations in OpenAlex.
- Climate-Sensitive Redistribution of Veterinary Parasites: An Attribution Framework for One Health Surveillance and Control.Biology · 2026Review
- Multiple anthelmintic resistance in Haemonchus contortus infecting sheep in Gangetic plains of India.Tropical animal health and production · 2026Article
- Evolutionary and epidemiological considerations for anthelmintic treatments in ruminant livestock.International journal for parasitology. Drugs and drug resistance · 2026Article
- Extensive parasite transmission and variation in a functional receptor associated with drug resistance in endemicScience advances · 2026Article
- Preliminary survey of anthelmintic efficacy in selected smallholder sheep and goat flocks in Sarawak, Malaysia.Tropical animal health and production · 2026Article
- The prevalence of E198A and F200Y single nucleotide polymorphism in Haemonchus contortus populations from Polish goat herds.Scientific reports · 2026Article
- Current issues in heartworm chemotherapy.Parasites & vectors · 2026Review
- Targeted supplementation with bioactive plants sustainably improves goat health and decreases antiparasitic drug use on smallholder farms.Scientific reports · 2026Article
- A Sustainable Strategy for Gastrointestinal Nematode Control in Sheep.Veterinary sciences · 2026Article
- Refining growth monitoring in lambs: dynamic growth curve modeling approach for targeted selective treatment.Tropical animal health and production · 2025Article
- Therapeutic efficacy of common anthelmintics used in the control of gastrointestinal nematodes in naturally infected sheep in Bishoftu, Central Ethiopia.Veterinary and animal science · 2025Article
- Surveillance of anthelmintic treatments on ruminant farms to detect resistance in a low-prevalence area.BMC veterinary research · 2025Article
- El Niño and La Niña differentially drive transmission dynamics of the small ruminant parasite Haemonchus contortus across agroecological zones in Southern Africa.Scientific reports · 2025Article
- Evaluation of nematode susceptibility and resistance to anthelmintic drugs with a WMicrotracker motility assay.Scientific reports · 2025Article
- Transformer-based deep learning enables improved B-cell epitope prediction in parasitic pathogens: A proof-of-concept study on Fasciola hepatica.PLoS neglected tropical diseases · 2025Article
- Efficacy of fenbendazole against gastrointestinal nematodes in naturally infected goats in Maputo Province, Mozambique using in vivo, in vitro and molecular assessment.International journal for parasitology. Drugs and drug resistance · 2025Article
- Prediction and Prioritisation of Novel Anthelmintic Candidates from Public Databases Using Deep Learning and Available Bioactivity Data Sets.International journal of molecular sciences · 2025Article
- Changes in equine strongylid communities after two decades of annual anthelmintic treatments at the farm level.Parasitology research · 2024Article
- Biotic interactions in soil and dung shape parasite transmission in temperate ruminant systems: An integrative framework.Ecological applications : a publication of the Ecological Society of America · 2024Review
- A phenotypic screen of the Global Health Priority Box identifies an insecticide with anthelmintic activity.Parasites & vectors · 2024Article
Corrections and comments
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Authors and funding
25 authors at 7 institutions in 2 countries.
Funding
Abstract
Anthelmintic resistance is a threat to global food security. In order to alleviate the selection pressure for resistance and maintain drug efficacy, management strategies increasingly aim to preserve a proportion of the parasite population in 'refugia', unexposed to treatment. While persuasive in its logic, and widely advocated as best practice, evidence for the ability of refugia-based approaches to slow the development of drug resistance in parasitic helminths is currently limited. Moreover, the conditions needed for refugia to work, or how transferable those are between parasite-host systems, are not known. This review, born of an international workshop, seeks to deconstruct the concept of refugia and examine its assumptions and applicability in different situations. We conclude that factors potentially important to refugia, such as the fitness cost of drug resistance, the degree of mixing between parasite sub-populations selected through treatment or not, and the impact of parasite life-history, genetics and environment on the population dynamics of resistance, vary widely between systems. The success of attempts to generate refugia to limit anthelmintic drug resistance are therefore likely to be highly dependent on the system in hand. Additional research is needed on the concept of refugia and the underlying principles for its application across systems, as well as empirical studies within systems that prove and optimise its usefulness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.