Evidence map›Paper›PMID 31125798›Full record

ArticleEpilepsy & behavior : E&B2019

Seizure severity is associated with poor quality of life in people living with epilepsy (PLWE) in Uganda: A cross-sectional study.

Mark Kaddumukasa, Levicatus Mugenyi, Samden Lhatoo, Nelson Sewankambo, Carol Blixen, Martha Sajatovic, Elly Katabira

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy & behavior : E&B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Mark KaddumukasaDepartment of Medicine, School of Medicine, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda. Electronic address: mkaddumukasa@chs.mak.ac.ug.
Levicatus MugenyiDepartment of Medicine, School of Medicine, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.
Samden LhatooDepartment of Neurology, The University of Texas, Health Science Center at Houston, 6431 Fannin Street - Suite MSB 7.044, Houston, TX 77030, USA. Electronic address: samden.d.lhatoo@uth.tmc.edu.
Nelson SewankamboDepartment of Medicine, School of Medicine, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda. Electronic address: sewankam@infocom.co.ug.
Carol BlixenNeurological and Behavioral Outcomes Center, University Hospitals Cleveland Medical Center & Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address: cxb28@case.edu.
Martha SajatovicNeurological and Behavioral Outcomes Center, University Hospitals Cleveland Medical Center & Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address: Martha.Sajatovic@UHhospitals.org.
Elly KatabiraDepartment of Medicine, School of Medicine, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda. Electronic address: katabira@imul.com.
Makerere University · UGCase Western Reserve University · USThe University of Texas Health Science Center at Houston · USUniversity Hospitals of Cleveland · US

Funding

Seizure frequency, Quality of Life and stigma reduction in people living with epilepsyK43TW010401 · FIC · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI KADDUMUKASA, MARK · 2017 to 2021
$589k
FIC NIH HHS K43 TW010401
6 · The paper itself

Abstract

rationaleThere is a paucity of information about the association of seizure severity and quality of life (QoL) in people living with epilepsy (PLWE) in sub-Saharan Africa. We evaluated the relationship between seizure severity and health-related quality of life (HRQoL) of patients with epilepsy being followed up in an outpatient neurology clinic in urban central Uganda.

methodsForty-eight PLWE who met the study inclusion criteria were enrolled. The study questionnaire was comprised of the Chalfont Seizure Severity Scale (CSSS) and the Quality of Life Inventory in Epilepsy (QOLIE-31). Spearman's rank correlation coefficient was used to determine the association between seizure severity and QoL score.

resultsThe median age of the study participants was 25 years, with median age (interquartile range (IQR)) of epilepsy onset of 12 (6-18) years. Over 57.4% of the study participants were unemployed. The mean (standard deviation (SD)) of QOLIE-31 and Seizure Severity Score was 62.5 (14.5) and 62.4 (1.6), respectively. There was no gender difference in the seizure severity scores (p = 0.451). An inverse relationship existed between seizure severity and the total QOLIE-31 score (Spearman's rank correlation coefficient, r = -0.48, p = 0.001), and seizure worry (r = -0.31, p = 0.030).

conclusionsIn this Ugandan sample, seizure severity is unacceptably high and directly impacts the life of PLWE. Interventions that reduce seizure severity are urgently needed in our settings to reduce seizures and improve the QoL in PLWE.

Indexed as

AdolescentAdultAnxietyChildCross-Sectional StudiesEpilepsyFemaleHumansMaleMiddle AgedQuality of LifeSeizuresSurveys and QuestionnairesUgandaYoung AdultEpilepsyQuality of lifeSeizureSeverity

Identifiers

PMID31125798
PMCPMC6597271
OpenAlexW2946626561

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.