Evidence map›Paper›PMID 31125411›Full record

ArticleJournal of the Pediatric Infectious Diseases Society2020

Determinants of Viral Resuppression or Persistent Virologic Failure After Initial Failure With Second-Line Antiretroviral Treatment Among Asian Children and Adolescents With HIV.

Sirinya Teeraananchai, Stephen J Kerr, Monica Gandhi, Viet Chau Do, Lam Van Nguyen, Dan Ngoc Hanh Tran, Pope Kosalaraksa, Thida Singtoroj, Narukjaporn Thammajaruk, Thidarat Jupimai and 1 more

Abstract read
In one paragraph

Article in Journal of the Pediatric Infectious Diseases Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sirinya TeeraananchaiHIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Stephen J KerrHIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Monica GandhiDivision of HIV, Infectious Diseases, and Global Medicine, San Francisco General Hospital, University of California San Francisco.
Viet Chau DoChildren's Hospital 2, Ho Chi Minh City, Vietnam.
Lam Van NguyenNational Hospital of Pediatrics, Hanoi, Vietnam.
Dan Ngoc Hanh TranChildren's Hospital 1, Ho Chi Minh City, Vietnam.
Pope KosalaraksaDivision of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Thailand.
Thida SingtorojTREAT Asia/amfAR-Foundation for AIDS Research, Bangkok, Thailand.
Narukjaporn ThammajarukHIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Thidarat JupimaiHIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Annette H SohnTREAT Asia/amfAR-Foundation for AIDS Research, Bangkok, Thailand.

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
Plugging Hair ARV Levels as Adherence Biomarkers into HIV Prevention TrialsR01AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GANDHI, MONICA · 2012 to 2021
$5.6M
“Hair Lengthening”: Using Hair Levels to Interpret Long-Acting PrEP Studies.R37AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2023 to 2026
$3.2M
NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI098472NIAID NIH HHS R37 AI098472
6 · The paper itself

Abstract

Of 56 children with perinatally acquired human immunodeficiency virus (HIV) who had been prescribed second-line protease inhibitor-based antiretroviral therapy and had ≥1 previous episode of viral failure (HIV RNA, ≥1000 copies/mL), 46% had ≥1, 34% had ≥2, and 23% had ≥3 consecutive episodes of viral failure during the 2 years of follow-up. Two of these children experienced a major protease inhibitor mutation.

Indexed as

MutationAdolescentAnti-Retroviral AgentsAsia, SoutheasternCD4 Lymphocyte CountChildChild, PreschoolFemaleHIV InfectionsHIV ProteaseHIV Protease InhibitorsHumansLongitudinal StudiesMaleTreatment FailureViral LoadAnti-Retroviral AgentsHIV ProteaseHIV Protease Inhibitorsadherencehair concentrationHIVsecond-line ARTvirologic failurevirologic resuppression

Identifiers

PMID31125411
PMCPMC7368343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.