ArticlePloS one2019
Pharmacokinetics of oral and subcutaneous meloxicam: Effect on indicators of pain and inflammation after knife castration in weaned beef calves.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Substance P concentrations in the blood plasma and serum of adult cattle and calves during different painful procedures and conditions - a systematic review.BMC veterinary research · 2022Pooled it
- Calves disbudded with local nerve block and analgesic show conditioned place aversion two days later but not in the hours post-disbudding.Animal welfare (South Mimms, England) · 2026Article
- Welfare of beef cattle.EFSA journal. European Food Safety Authority · 2025Article
- Self-Administration of Meloxicam via Medicated Molasses Lick Blocks May Improve Welfare of Castrated Calves.Animals : an open access journal from MDPI · 2025Article
- Pharmacokinetics of Meloxicam in Different Animal Species: A Comprehensive Review.Veterinary sciences · 2024Review
- Production and certification of BOTS-1: bovine muscle-certified reference material for incurred veterinary drug residues.Analytical and bioanalytical chemistry · 2024Article
- Role of Topical Anaesthesia in Pain Management of Farm Animals, a Changing Paradigm.Animals : an open access journal from MDPI · 2022Review
- Article
- Pharmacokinetic Parameters and Tissue Withdrawal Intervals for Sheep Administered Multiple Oral Doses of Meloxicam.Animals : an open access journal from MDPI · 2021Article
- Unmitigated Surgical Castration in Calves of Different Ages: Electroencephalographic and Neurohormonal Findings.Animals : an open access journal from MDPI · 2021Article
- Analgesia for Sheep in Commercial Production: Where to Next?Animals : an open access journal from MDPI · 2021Review
- Repeatability and Feasibility of Pressure Algometry for Quantifying Mechanical Nociceptive Threshold in the Thoracic Region of Calves.Frontiers in veterinary science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral meloxicam is labelled for reducing pain and inflammation associated with castration in cattle in Canada, however, subcutaneous meloxicam is only labelled for pain associated with dis-budding and abdominal surgery. The aim of this project was to determine the pharmacokinetic profile of oral (PO; 1.0 mg/kg BW) and subcutaneous meloxicam (SC; 0.5 mg/kg BW), and to assess the effect of meloxicam on physiological and behavioural indicators of pain associated with knife castration in 7-8 month old calves. Twenty-three Angus crossbred beef calves (328 ± 4.4 kg BW) were randomly assigned to two treatments: PO n = 12 or SC n = 11 administration of meloxicam immediately before knife castration. Physiological parameters included salivary and hair cortisol, substance P, haptoglobin, serum amyloid-A, weight, complete blood count, scrotal and rectal temperature. Behavioural parameters included standing and lying behaviour, pen behaviour and feeding behaviour. Data were analyzed using PROC GLIMMIX (SAS), with repeated measures using mixed procedures including treatment as a fixed effect and animal and pen as a random effect. The pharmacokinetic profile of the drug including area under the curve, volume of distribution and clearance was greater (P < 0.05) in PO than SC calves. After surgery, substance P concentrations, white blood cell counts (WBC), weight and lying duration were greater (P < 0.05) in PO than SC calves, while scrotal circumference was lower (P < 0.05) in PO calves than SC calves. Although statistical differences were observed for pharmacokinetic, physiological and behavioural parameters differences were small and may lack biological relevance.
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Registered trials
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