Evidence map›Paper›PMID 31125264›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2019

Prenatal inflammation impairs intestinal microvascular development through a TNF-dependent mechanism and predisposes newborn mice to necrotizing enterocolitis.

Xiaocai Yan, Elizabeth Managlia, Xiao-Di Tan, Isabelle G De Plaen

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 39 citations in OpenAlex.

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  11. Mechanisms and functions of intestinal vascular specialization.The Journal of experimental medicine · 2024
    Review
  12. Article
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  14. State-of-the-art review and update ofFrontiers in pediatrics · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Xiaocai YanDivision of Neonatology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Feinberg School of Medicine , Chicago, Illinois.
Elizabeth ManagliaDivision of Neonatology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Feinberg School of Medicine , Chicago, Illinois.
Xiao-Di TanDivision of Gastroenterology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Feinberg School of Medicine , Chicago, Illinois.
Isabelle G De PlaenDivision of Neonatology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Feinberg School of Medicine , Chicago, Illinois.
Lurie Children's Hospital · USNorthwestern University · US

Funding

Role of the intestinal microvasculature in necrotizing enterocolitisR01DK116568 · NIDDK · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI DE PLAEN, ISABELLE G · 2019 to 2023
$2.7M
Surgical studies of gut epithelial apoptosis-initiated critical illnessR01GM117628 · NIGMS · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI TAN, XIAO-DI · 2016 to 2019
$1.9M
Mechanisms underlying disruption of intestinal epithelial barrier in critical illnessR01GM122406 · NIGMS · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI TAN, XIAO-DI · 2017 to 2018
$594k
NIDDK NIH HHS R01 DK116568NIGMS NIH HHS R01 GM117628NIGMS NIH HHS R01 GM122406
6 · The paper itself

Abstract

Prenatal inflammation is a risk factor for necrotizing enterocolitis (NEC), and it increases intestinal injury in a rat NEC model. We previously showed that maldevelopment of the intestinal microvasculature and lack of vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) signaling play a role in experimental NEC. However, whether prenatal inflammation affects the intestinal microvasculature remains unknown. In this study, mouse dams were injected intraperitoneally with lipopolysaccharide (LPS) or saline at

Indexed as

Neovascularization, PhysiologicPrenatal Exposure Delayed EffectsAnimalsCapillary PermeabilityCell ProliferationCells, CulturedDisease Models, AnimalEndothelial CellsEnterocolitis, NecrotizingFemaleGestational AgeHypoxia-Inducible Factor 1, alpha SubunitInflammationIntestine, SmallLipopolysaccharidesMice, Inbred C57BLHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitKdr protein, mouseLipopolysaccharidesTnf protein, mouseTumor Necrosis Factor-alphaVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseVascular Endothelial Growth Factor Receptor-2endothelial cellsinflammationintestinal microvasculaturenecrotizing enterocolitisneonate

Identifiers

PMID31125264
PMCPMC6689733
OpenAlexW2945249727

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.