Evidence map›Paper›PMID 31125214›Full record

ArticleInorganic chemistry2019

Platinum(IV)-Ferrocene Conjugates and Their Cyclodextrin Host-Guest Complexes.

Grégory Thiabaud, Louis Harden-Bull, Yoo-Jin Ghang, Sajal Sen, Xiaodong Chi, James L Bachman, Vincent M Lynch, Zahid H Siddik, Jonathan L Sessler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inorganic chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Investigation of new ferrocenyl-artesunate derivatives as antiparasitics.Dalton transactions (Cambridge, England : 2003) · 2023
    Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Grégory ThiabaudDepartment of Chemistry , The University of Texas at Austin , 100 E. 24th Street , Austin , Texas 78712 , United States.ORCID http://orcid.org/0000-0001-5189-8445
Louis Harden-BullDepartment of Chemistry , The University of Texas at Austin , 100 E. 24th Street , Austin , Texas 78712 , United States.
Yoo-Jin GhangDepartment of Chemistry , The University of Texas at Austin , 100 E. 24th Street , Austin , Texas 78712 , United States.
Sajal SenDepartment of Chemistry , The University of Texas at Austin , 100 E. 24th Street , Austin , Texas 78712 , United States.
Xiaodong ChiDepartment of Chemistry , The University of Texas at Austin , 100 E. 24th Street , Austin , Texas 78712 , United States.
James L BachmanDepartment of Chemistry , The University of Texas at Austin , 100 E. 24th Street , Austin , Texas 78712 , United States.
Vincent M LynchDepartment of Chemistry , The University of Texas at Austin , 100 E. 24th Street , Austin , Texas 78712 , United States.
Zahid H SiddikThe University of Texas M. D. Anderson Cancer Center , 1515 Holcombe Boulevard, Unit Number 1950 , Houston , Texas 77030 , United States.
Jonathan L SesslerDepartment of Chemistry , The University of Texas at Austin , 100 E. 24th Street , Austin , Texas 78712 , United States.ORCID http://orcid.org/0000-0002-9576-1325
The University of Texas at Austin · USThe University of Texas MD Anderson Cancer Center · US

Funding

Biomedical Applications of Expanded Porphyrins: Development of Gold-Texaphyrin ConjugatesR01CA068682 · NCI · UNIVERSITY OF TEXAS AUSTIN · PI Esther Y. Maier, Emily L Que · 1995 to 2026
$7.4M
Bruker AVANCE III HD 500 MHz NMRS10OD021508 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI SESSLER, JONATHAN L · 2016 to 2016
$529k
SYNTHESIS OF SPONGISTATIN, A NOVEL CYTOTOXIC AGENTF32CA068686 · NCI · HARVARD UNIVERSITY · PI SCHRIMPF, MICHAEL R · 1995 to 1996
–
NCI NIH HHS F32 CA068686NCI NIH HHS R01 CA068682NIH HHS S10 OD021508
6 · The paper itself

Abstract

Reported here are new platinum(IV) (Pt(IV)) complexes bearing ferrocene (Fc) moieties. These systems differ from one another only by the nature of the functional group (ester vs amide) connecting the linker to the Fc subunits. This minor structural variation (one atom difference) leads to major differences in solubility, stability, and antiproliferative activity against lung (A549) cancer cells. The host-guest chemistry of these complexes was investigated in an aqueous medium in the presence of β-cyclodextrins (β-CD), either free or in the form of a covalently linked Fc-Pt-β-CD hybrid. An inclusion complex between Fc and β-CD is formed in aqueous media, presumably as a result of hydrophobic interactions involving the Fc and the inner β-CD cavity. Consequently, it proved possible to use a β-CD-based strategy to purify the Pt-Fc conjugates in this study under aqueous conditions (by means of C18 silica gel columns). The use of a β-CD adjuvant also allowed dimethyl sulfoxide (DMSO) to be avoided as an organic cosolvent in cell studies. The amide version reported here (2) proved to be more soluble, more stable, and more active than the ester analogue (11) in A549 cells. The use of a β-CD functionalized with a fluorescent probe allowed intracellular Pt-Fc localization to be visualized by confocal fluorescence microscopy.

Identifiers

PMID31125214
PMCPMC6953482
OpenAlexW2945861018

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.