Evidence map›Paper›PMID 31124389›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2019

Stereoselective pharmacokinetic and pharmacodynamic analysis of a CNS-active sulphamoylphenyl carbamate derivative.

David Bibi, Bella Shusterman, Alessio Nocentini, Claudiu T Supuran, Meir Bialer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

David Bibia Faculty of Medicine, School of Pharmacy, Institute of Drug Research , The Hebrew University of Jerusalem , Jerusalem , Israel.
Bella Shustermana Faculty of Medicine, School of Pharmacy, Institute of Drug Research , The Hebrew University of Jerusalem , Jerusalem , Israel.
Alessio Nocentinib Department of Neurofarba , University of Florence , Florence , Italy.
Claudiu T Supuranb Department of Neurofarba , University of Florence , Florence , Italy.ORCID http://orcid.org/0000-0003-4262-0323
Meir Bialera Faculty of Medicine, School of Pharmacy, Institute of Drug Research , The Hebrew University of Jerusalem , Jerusalem , Israel.
Hebrew University of Jerusalem · ILUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3-Methylpentyl(4-sulphamoylphenyl)carbamate (MSPC) came as the most potent compound out of a new series of carbamates composed of phenyl-ethanol or branched aliphatic alcohols, and 4-benzenesulphonamide-carbamic acid. In this study, the anticonvulsant activity and pharmacokinetics (PKs) of MSPC-two individual enantiomers were comparatively analysed in rats as well as their carbonic anhydrase (CA) inhibition. The anticonvulsant activity of MSPC enantiomers was evaluated at the rat-maximal electroshock (MES) test, and their CA inhibition evaluated. (R)-MSPC had a 29% higher clearance and consequently, a lower plasma exposure area under the curve (AUC) than (S)-MSPC and racemic-MSPC. Nevertheless, (R)-MSPC had a better brain permeability than its (S)-enantiomer with brain-to-plasma-(AUC)-ratio (BPR) of 2.07 ((R)-enantiomer), 1.85 (racemate), and 0.79 ((S)-enantiomer). As a whole body (

Indexed as

AnimalsAnticonvulsantsCarbamatesCarbonic Anhydrase InhibitorsCarbonic AnhydrasesCentral Nervous SystemCentral Nervous System AgentsDose-Response Relationship, DrugMaleMolecular StructureRatsRats, Sprague-DawleyStereoisomerismStructure-Activity Relationship3-methylpentyl(4-sulphamoylphenyl)carbamateAnticonvulsantsCarbamatesCarbonic Anhydrase InhibitorsCarbonic AnhydrasesCentral Nervous System Agents4-aminobenzenesulphonamidescarbonic anhydrase inhibitionCNS-active carbamatesNew antiepileptic drugspharmacokinetics

Identifiers

PMID31124389
PMCPMC6534253
OpenAlexW2945961711

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.