ArticleJournal of Korean medical science2019
Comparative Analysis of Phase Lag Entropy and Bispectral Index as Anesthetic Depth Indicators in Patients Undergoing Thyroid Surgery with Nerve Integrity Monitoring.
Article in Journal of Korean medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05148065 (Analysis of Relationship Between Depth of Anesthesia by Inhalation Anesthetic and Primitive Electroencephalogram in Children Under Two Years of Age), which is not on this map. Cited by 8 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Analysis of Relationship Between Depth of Anesthesia by Inhalation Anesthetic and Primitive Electroencephalogram in Children Under Two Years of Age: a Prospective Observational Study
Who cites it
8 citing papers in PubMed.
- The influence of neuromuscular blockade on phase lag entropy and bispectral index: A randomized, controlled trial.PloS one · 2021Trial
- Effect of depth of anesthesia on the phase lag entropy in patients undergoing general anesthesia by propofol: A STROBE-compliant study.Medicine · 2020Trial
- Comparative analysis of processed EEG indices and entropy-based metrics for assessing anesthetic depth: a scoping review - PRISMA-ScR.BMC biomedical engineering · 2026Article
- Phase Lag Entropy as a Surrogate Measurement of Hypnotic Depth during Sevoflurane Anesthesia.Medicina (Kaunas, Lithuania) · 2021Article
- A new anesthesia scheme for parathyroidectomy under neuromonitoring: a retrospective cohort study.Gland surgery · 2021Article
- Do epoch lengths of hypnotic depth indicators affect estimated of blood-brain equilibration rate constants of propofol?Journal of pharmacokinetics and pharmacodynamics · 2021Article
- Consciousness and complexity: a consilience of evidence.Neuroscience of consciousness · 2021Review
- Monitoring of anesthetic depth and EEG band power using phase lag entropy during propofol anesthesia.BMC anesthesiology · 2020Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundMost depth of anesthesia (DOA) monitors rely on the temporal characteristics of a single-channel electroencephalogram (EEG) and cannot provide spatial or connectivity information. Phase lag entropy (PLE) reflects DOA by calculating diverse connectivity from temporal patterns of phase relationships. The aim of this study was to compare the performance of PLE and bispectral index (BIS) monitors for assessing DOA during anesthesia induction, nerve integrity monitoring (NIM), and anesthesia emergence.
methodsThirty-five patients undergoing elective thyroid surgery with recurrent laryngeal nerve NIM received propofol and remifentanil via target-controlled infusion. After applying PLE and BIS monitors, propofol infusion was initiated at a calculated effect site concentration (Ce) of 2 μg/mL and then increased in 1-μg/mL Ce increments. After propofol Ce reached 5 μ/mL, a remifentanil infusion was begun, and anesthesia induction was considered complete. During NIM, PLE and BIS values were compared at a specific time points from platysma muscle exposure to subcutaneous tissue closure. PLE and BIS values were recorded continuously from preanesthetic state to full recovery of orientation; bias and limits of agreement between monitors were calculated.
resultsPLE and BIS values decreased progressively with increasing propofol Ce during anesthetic induction and increased by stages during emergence. The prediction probabilities of PLE and BIS for detecting propofol Ce changes were 0.750 and 0.756, respectively, during induction and 0.749 and 0.746, respectively, during emergence. No aberrant PLE or BIS values occurred during NIM. Correlation coefficients for BIS and PLE were 0.98 and 0.92 during induction and emergence, respectively. PLE values were significantly higher than BIS values at full recovery of orientation. Estimated bias between monitors was -4.16 ± 8.7, and 95% limits of agreement were -21.21 to 12.89.
conclusionPLE is a reasonable alternative to BIS for evaluating consciousness and DOA during general anesthesia and during NIM.
trial registrationClinical Research Information Service Identifier: KCT0003490.
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