ArticleBritish journal of pharmacology2019
Ca
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In one paragraph
Article in British journal of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
12.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Therapeutic efficacy of celastrol in experimental polyarthritis: insights from a meta-analysis of in vivo studies.Inflammopharmacology · 2025Pooled it
- Molecular insights into phytochemicals exhibiting anti-arthritic activity: systematic review : John Di Battista.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Pooled it
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)Autophagy · 2021Guideline
- Delta-3-Carene Presented Anti-Inflammatory and Antinociceptive Properties by Modulating Leukocyte Activation in the Experimental Inflammatory Response In Vitro and In Vivo.Molecules (Basel, Switzerland) · 2026Article
- Folate-modified liposomal celastrol for rheumatoid arthritis: therapeutic efficacy and modulation of ROS/NF-κB/COX-2-related inflammatory signaling.Frontiers in immunology · 2026Article
- Synovium-On-A-Chip: Simulating the Microenvironment of the Rheumatoid Arthritis Synovium via Multicell Interactions to Target Fibroblast-Like Synoviocytes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Pharmacological modes of plant-derived compounds for targeting inflammation in rheumatoid arthritis: A comprehensive review on immunomodulatory perspective.Inflammopharmacology · 2025Review
- Recombinant high-density lipoprotein targeted delivery of celastrol to promote foam cells lipophagy against early atherosclerosis.Journal of nanobiotechnology · 2025Article
- Protective effects of Catalpol to attenuate TNF- α and collagen-induced inflammation in vitro HFLS-RA cells and in vivo mice models for the treatment of rheumatoid arthritis.Clinical rheumatology · 2025Article
- Identification and assessment of hub genes and miRNAs coregulatory associated with immune infiltrations and drug interactions in latent tuberculosis based on MicroarrayData analysis, molecular docking, and dynamic simulation.Biochemistry and biophysics reports · 2025Article
- The role of celastrol in inflammation and diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- A comprehensive review of natural products in rheumatoid arthritis: therapeutic potential and mechanisms.Frontiers in immunology · 2025Review
- Triterpenoid Compounds and their Derivatives: Emerging Pharmacological Agents for Arthritis Treatment.Mini reviews in medicinal chemistry · 2025Review
- Progress in the application of epimedium and its major bioactive components in the treatment of orthopedic diseases.Frontiers in pharmacology · 2025Review
- Programmed Cell Death in Rheumatoid Arthritis.Journal of inflammation research · 2025Review
- ML385, an Nrf2 Inhibitor, Synergically Enhanced Celastrol Triggered Endoplasmic Reticulum Stress in Lung Cancer Cells.ACS omega · 2024Article
- Promising and challenging phytochemicals targeting LC3 mediated autophagy signaling in cancer therapy.Immunity, inflammation and disease · 2024Review
- Exploring the mechanism of Celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omics.Scientific reports · 2024Article
- Exploring the pharmacological mechanisms of Shuanghuanglian against T-cell acute lymphoblastic leukaemia through network pharmacology combined with molecular docking and experimental validation.Pharmaceutical biology · 2023Article
- The potential development of drug resistance in rheumatoid arthritis patients identified with p53 mutations.Genes & diseases · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 5 institutions in 4 countries.
Vincent Kam Wai WongState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.ORCID 0000-0002-2951-8108
Congling QiuState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Su-Wei XuState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Betty Yuen Kwan LawState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Wu ZengState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Hui WangState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Francesco MichelangeliDepartment of Biological Sciences, University of Chester, Chester, UK.
Ivo Ricardo De Seabra Rodrigues DiasState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Yuan Qing QuState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Tsz Wai ChanState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Yu HanState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Ni ZhangState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Simon Wing Fai MokState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Xi ChenState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Lu YuState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Hudan PanState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Sami HamdounDepartment of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Mainz, Germany.
Thomas EfferthDepartment of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Mainz, Germany.
Wen Jing YuState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Wei ZhangState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Zheng LiState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Yuesheng XieGuangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Riqiang LuoGuangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Quan JiangDepartment of Rheumatology, Guang-An-Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Liang LiuState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Macau University of Science and Technology · MOGuangdong General Hospital · CNUniversity of Applied Sciences Mainz · DEChinese Academy of Medical Sciences & Peking Union Medical College · CNUniversity of Chester · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeCelastrol exhibits anti-arthritic effects in rheumatoid arthritis (RA), but the role of celastrol-mediated Ca EXPERIMENTAL APPROACH: We used computational docking, Ca KEY
resultsCelastrol inhibited SERCA to induce autophagy-dependent cytotoxicity in RASFs/RAFLS via Ca CONCLUSION AND IMPLICATIONS: Celastrol triggered Ca
Indexed as
AnimalsArthritis, ExperimentalArthritis, RheumatoidAutophagyCalcium SignalingCells, CulturedFibroblastsGene Expression RegulationHumansMaleMice, KnockoutPentacyclic TriterpenesRats, Sprague-DawleySarcoplasmic Reticulum Calcium-Transporting ATPasesSynovial MembraneTriterpenescelastrolPentacyclic TriterpenesSarcoplasmic Reticulum Calcium-Transporting ATPasesTriterpenes
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LicenceCC BY-NC
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.