Evidence map›Paper›PMID 31124136›Full record

ArticleThe Journal of physiology2019

Advanced age protects resistance arteries of mouse skeletal muscle from oxidative stress through attenuating apoptosis induced by hydrogen peroxide.

Charles E Norton, Shenghua Y Sinkler, Nicole L Jacobsen, Steven S Segal

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  5. Differential Effects of High Fat Diets on Resilience to HAntioxidants (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Vascular calcium signalling and ageing.The Journal of physiology · 2021
    Review
  8. Review
  9. Aging Alters Cerebrovascular Endothelial GPCR and K+ Channel Function: Divergent Role of Biological Sex.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Article
  10. Review
  11. Endothelial calreticulin deletion impairs endothelial function in aged mice.American journal of physiology. Heart and circulatory physiology · 2020
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Charles E NortonDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, 65212, USA.
Shenghua Y SinklerDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, 65212, USA.
Nicole L JacobsenDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, 65212, USA.
Steven S SegalDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, 65212, USA.ORCID 0000-0001-5667-2154
University of Missouri · USHamilton Medical Center · US

Funding

Intercellular Coordination of Blood Flow ControlR37HL041026 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SEGAL, STEVEN S · 2008 to 2018
$3.7M
Microcirculation in Aging Skeletal MuscleR01HL086483 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SEGAL, STEVEN S · 2007 to 2012
$2.4M
INTERCELLULAR COORDINATION OF BLOOD FLOW CONTROLR01HL041026 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SEGAL, STEVEN S · 1996 to 2004
$1.4M
NHLBI NIH HHS R01 HL041026NHLBI NIH HHS R01 HL086483NHLBI NIH HHS R37 HL041026
6 · The paper itself

Abstract

key pointsVascular oxidative stress increases with advancing age. We hypothesized that resistance vessels develop resilience to oxidative stress to protect functional integrity and tested this hypothesis by exposing isolated pressurized superior epigastric arteries (SEAs) of old and young mice to H ABSTRACT: Advanced age is associated with elevated oxidative stress and can protect the endothelium from cell death induced by H

Indexed as

ApoptosisOxidative StressAgingAnimalsCalciumEndothelium, VascularEpigastric ArteriesHydrogen PeroxideMaleMiceMice, Inbred C57BLMuscle, SkeletalMuscle, Smooth, VascularCalciumHydrogen Peroxidecaspasescytochrome Cendotheliumhydrogen peroxidenitric oxide

Identifiers

PMID31124136
PMCPMC7365254
OpenAlexW2945169705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.