Evidence map›Paper›PMID 31124078›Full record

ArticleMolecular neurobiology2019

Palbociclib Effectively Halts Proliferation but Fails to Induce Senescence in Patient-Derived Glioma Stem Cells.

Olivia Morris-Hanon, Mariela Claudia Marazita, Leonardo Romorini, Luciana Isaja, Damián Darío Fernandez-Espinosa, Gustavo Emilio Sevlever, María Elida Scassa, Guillermo Agustín Videla-Richardson

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Adjuvant Palbociclib for Early Breast Cancer: The PALLAS Trial Results (ABCSG-42/AFT-05/BIG-14-03).Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Trial
  2. Review
  3. Article
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  5. Article
  6. Article
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  9. Article
  10. Cellular enlargement - A new hallmark of aging?Frontiers in cell and developmental biology · 2022
    Review
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  12. Article
  13. Review
  14. Short-term CDK4/6 Inhibition Radiosensitizes Estrogen Receptor-Positive Breast Cancers.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Olivia Morris-HanonLaboratorial de Investigación aplicada a Neurociencias (LIAN), Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Ruta 9, Km 52.5, B1625XAF, Buenos Aires, Argentina.
Mariela Claudia MarazitaLaboratorial de Investigación aplicada a Neurociencias (LIAN), Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Ruta 9, Km 52.5, B1625XAF, Buenos Aires, Argentina.
Leonardo RomoriniLaboratorial de Investigación aplicada a Neurociencias (LIAN), Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Ruta 9, Km 52.5, B1625XAF, Buenos Aires, Argentina.
Luciana IsajaLaboratorial de Investigación aplicada a Neurociencias (LIAN), Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Ruta 9, Km 52.5, B1625XAF, Buenos Aires, Argentina.
Damián Darío Fernandez-EspinosaLaboratorial de Investigación aplicada a Neurociencias (LIAN), Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Ruta 9, Km 52.5, B1625XAF, Buenos Aires, Argentina.
Gustavo Emilio SevleverLaboratorial de Investigación aplicada a Neurociencias (LIAN), Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Ruta 9, Km 52.5, B1625XAF, Buenos Aires, Argentina.
María Elida ScassaLaboratorial de Investigación aplicada a Neurociencias (LIAN), Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Ruta 9, Km 52.5, B1625XAF, Buenos Aires, Argentina.
Guillermo Agustín Videla-RichardsonLaboratorial de Investigación aplicada a Neurociencias (LIAN), Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Ruta 9, Km 52.5, B1625XAF, Buenos Aires, Argentina. willyvidelar@hotmail.com.ORCID http://orcid.org/0000-0002-0015-7687
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma multiforme is the most aggressive primary brain tumor. Current knowledge suggests that the growth and recurrence of these tumors are due in part to the therapy-resistant glioma stem cell subpopulation, which possesses the ability for self-renewal and proliferation, driving tumor progression. In many cancers, the p16

Indexed as

ApoptosisBrain NeoplasmsCell Cycle CheckpointsCell Line, TumorCell ProliferationCellular SenescenceCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6FibroblastsGliomaHumansNeoplastic Stem CellsPhenotypePiperazinesPyridinesRoscovitineCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6palbociclibPiperazinesPyridinesRoscovitineCDK4/6Glioma stem cellsPalbociclibQuiescenceSenescence

Identifiers

PMID31124078
OpenAlexW2945182925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.