Evidence map›Paper›PMID 31123994›Full record

ArticleNeurocritical care2019

Prioritization and Timing of Outcomes and Endpoints After Aneurysmal Subarachnoid Hemorrhage in Clinical Trials and Observational Studies: Proposal of a Multidisciplinary Research Group.

Martin N Stienen, Johanna M Visser-Meily, Tom A Schweizer, Daniel Hänggi, R Loch Macdonald, Mervyn D I Vergouwen, Unruptured Intracranial Aneurysms and SAH CDE Project Investigators

Open access · greenAbstract readConsensus Development Conference, NIH
PubMed Publisher
In one paragraph

Article in Neurocritical care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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  18. Patient-reported outcome and cognitive measures to be used in vascular and brain tumor surgery: proposal for a minimum set.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
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  19. Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Martin N StienenDepartment of Neurosurgery, UniversitätsSpital Zürich, Clinical Neuroscience Center, University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland. mnstienen@gmail.com.ORCID http://orcid.org/0000-0003-0548-9936
Johanna M Visser-MeilyDepartment of Rehabilitation, Physical Therapy Science and Sports, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Tom A SchweizerDivision of Neurosurgery, Department of Surgery, St. Michael's Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre for Biomedical Research and Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Canada.
Daniel HänggiDepartment of Neurosurgery, University Medical Center Mannheim, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
R Loch MacdonaldDivision of Neurosurgery, Department of Surgery, St. Michael's Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre for Biomedical Research and Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Canada.
Mervyn D I VergouwenDepartment of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Unruptured Intracranial Aneurysms and SAH CDE Project Investigators
St. Michael's Hospital · CAUniversity of Zurich · CHUniversity Medical Center Utrecht · NL

Funding

Medical Research Council G1002605NINDS NIH HHS HHSN271201200034C
6 · The paper itself

Abstract

introductionIn studies on aneurysmal subarachnoid hemorrhage (SAH), substantial variability exists in the use and timing of outcomes and endpoints, which complicates interpretation and comparison of results between studies. The aim of the National Institute of Health/National Institute of Neurological Disorders and Stroke/National Library of Medicine Unruptured Intracranial Aneurysm (UIA) and SAH common data elements (CDE) Project was to provide a common structure for future UIA and SAH research.

methodsThis article summarizes the recommendations of the UIA and SAH CDE Outcomes and Endpoints subgroup, which consisted of an international and multidisciplinary ad hoc panel of experts in clinical outcomes after SAH. Consensus recommendations were developed by review of previously published CDEs for other neurological diseases and the SAH literature. Recommendations for CDEs were classified by priority into "Core," "Supplemental-Highly Recommended," "Supplemental," and "Exploratory."

resultsThe subgroup identified over 50 outcomes measures and template case report forms (CRFs) to be included as part of the UIA and SAH CDE recommendations. None was classified as "Core". The modified Rankin Scale score and Montreal Cognitive Assessment were considered the preferred outcomes and classified as Supplemental-Highly Recommended. Death, Glasgow Outcome Scale score, and Glasgow Outcome Scale-extended were classified as Supplemental. All other outcome measures were categorized as "Exploratory". We propose outcome assessment at 3 months and at 12 months for studies interested in long-term outcomes. We give recommendations for standardized dichotomization.

conclusionThe recommended outcome measures and CRFs have been distilled from a broad pool of potentially useful CDEs, scales, instruments, and endpoints. The adherence to these recommendations will facilitate the comparison of results across studies and meta-analyses of individual patient data.

Indexed as

Common Data ElementsOutcome Assessment, Health CareAneurysm, RupturedBiomedical ResearchClinical Trials as TopicHumansIntracranial AneurysmNational Institute of Neurological Disorders and Stroke (U.S.)National Library of Medicine (U.S.)Observational Studies as TopicSubarachnoid HemorrhageTime FactorsUnited StatesAneurysmClinical studiesCommon data elementsData codingData collectionEndpointsHemorrhagic strokeMoCAModified Rankin ScaleMontreal Cognitive AssessmentmRSOutcomesStandardizationSubarachnoid hemorrhage

Identifiers

PMID31123994
OpenAlexW2944946142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.