Evidence map›Paper›PMID 31123980›Full record

ArticleClinical journal of gastroenterology2019

A case of Ménétriere´s disease treated with the monoclonal antibody cetuximab.

Arne Carlsen, Tore Bjørn Grimstad, Lars Normann Karlsen, Ole Jacob Greve, Katrine Brække Norheim, Dordi Lea

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Clinical journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Ménétrier disease: A clinical review.World journal of gastroenterology · 2025
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Arne CarlsenGastroenterology Unit, Department of Internal Medicine, Stavanger University Hospital, P.O. Box 8100, 4068, Stavanger, Norway. acarlsen@yahoo.com.ORCID http://orcid.org/0000-0002-6005-6394
Tore Bjørn GrimstadGastroenterology Unit, Department of Internal Medicine, Stavanger University Hospital, P.O. Box 8100, 4068, Stavanger, Norway.
Lars Normann KarlsenGastroenterology Unit, Department of Internal Medicine, Stavanger University Hospital, P.O. Box 8100, 4068, Stavanger, Norway.
Ole Jacob GreveDepartment of Radiology, Stavanger University Hospital, Stavanger, Norway.
Katrine Brække NorheimClinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway.
Dordi LeaDepartment of Pathology, Stavanger University Hospital, Stavanger, Norway.
Stavanger University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ménétriere´s disease is a rare disorder of the body and fundus of the stomach, characterized by a massive proliferation of the foveolar cells and subsequent excess mucous secretion. This results in hypoproteinemia due to loss of serum proteins across the gastric mucosa. The cause of Ménétriere´s disease is unknown, and due to the irreversible and premalignant character of the disorder, the patients affected have been subdued to gastrectomy as the only curable treatment. Epidermial growth factor (EGF) has been implicated in the pathogenesis, a finding that makes the disorder receptive to monoclonal antibody treatment against the EGF receptor. In this case report, we present a 41-year-old woman referred to our emergency department due to dizziness, nausea, and vomiting. A thorough medical investigation, combining clinical history, laboratory investigations, an upper endoscopy with full-thickness snare biopsies, and a CT scan confirmed Ménétriere´s disease, and she was successfully treated with the monoclonal antibody cetuximab.

Indexed as

AdultAntibodies, Monoclonal, HumanizedCetuximabDrug Administration ScheduleFemaleGastritis, HypertrophicGastrointestinal AgentsHumansInfusions, IntravenousOff-Label UseTreatment OutcomeAntibodies, Monoclonal, HumanizedCetuximabGastrointestinal AgentsCetuximabEpidermial growth factor receptorHypoproteinemic hypertrophic gastropathyMénétriere´s disease

Identifiers

PMID31123980
PMCPMC6885025
OpenAlexW2945843614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.