Evidence map›Paper›PMID 31123892›Full record

ReviewCurrent topics in microbiology and immunology2019

Helicobacter pylori Deregulates T and B Cell Signaling to Trigger Immune Evasion.

Victor E Reyes, Alex G Peniche

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in microbiology and immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
40.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Mitochondrial Stress inAntioxidants (Basel, Switzerland) · 2026
    Review
  3. The Potential Role ofMicroorganisms · 2025
    Review
  4. Article
  5. Review
  6. Beyond the stomach: the association betweenFrontiers in cellular and infection microbiology · 2025
    Review
  7. Article
  8. CD4European journal of medical research · 2024
    Article
  9. Review
  10. Microorganisms · 2024
    Review
  11. Article
  12. Pivotal role ofFrontiers in medicine · 2024
    Review
  13. Impact ofJournal for immunotherapy of cancer · 2023
    Article
  14. Heliyon · 2023
    Article
  15. Medical research archives · 2022
    Article
  16. Innate Immunity Crosstalk withInternational journal of molecular sciences · 2022
    Review
  17. The immune microenvironment in gastric adenocarcinoma.Nature reviews. Gastroenterology & hepatology · 2022
    Review
  18. Article
  19. Emerging Role ofFrontiers in oncology · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Victor E ReyesDepartment of Pediatrics, The University of Texas Medical Branch at Galveston, Galveston, TX, USA. vreyes@utmb.edu.
Alex G PenicheDepartment of Pediatrics, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
The University of Texas Medical Branch at Galveston · US

Funding

Immune Evasion by H. pyloriR56DK090090 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI REYES, VICTOR E. · 2010 to 2010
$395k
Protein Biomarkers of Gastric CancerR21CA127022 · NCI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI REYES, VICTOR E. · 2009 to 2010
$365k
NCI NIH HHS R21 CA127022NIDDK NIH HHS R56 DK090090
6 · The paper itself

Abstract

Helicobacter pylori is a prevalent human pathogen that successfully establishes chronic infection, which leads to clinically significant gastric diseases including chronic gastritis, peptic ulcer disease (PUD), and gastric cancer (GC). H. pylori is able to produce a persistent infection due in large part to its ability to hijack the host immune response. The host adaptive immune response is activated to strategically and specifically attack pathogens and normally clears them from the infected host. Since B and T lymphocytes are central mediators of adaptive immunity, in this chapter we review their development and the fundamental mechanisms regulating their activation in order to understand how some of the normal processes are subverted by H. pylori. In this review, we place particular emphasis on the CD4

Indexed as

Immune EvasionB-LymphocytesGastric MucosaHelicobacter InfectionsHelicobacter pyloriHumansT-LymphocytesCo-inhibitory receptorsImmune checkpoint regulatorsImmune evasionLymphocyte developmentReprogramming

Identifiers

PMID31123892
PMCPMC7050993
OpenAlexW2946204900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.