Evidence map›Paper›PMID 31123865›Full record

ArticleEuropean journal of nutrition2020

Plasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 study.

Anupam Chandra, Helge Røsjø, Ivar Anders Eide, Thea Vigen, Håkon Ihle-Hansen, Eivind Bjørkan Orstad, Ole Morten Rønning, Magnus Nakrem Lyngbakken, Trygve Berge, Erik Berg Schmidt and 3 more

Registry-linked trialOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01555411 (Akershus Cardiac Examination 1950 Study - a Cohort Study on Cardio- and Cerebrovascular Disease in 62-65-year-old Subjects), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01555411 active not recruitingnot on this map

Akershus Cardiac Examination 1950 Study - a Cohort Study on Cardio- and Cerebrovascular Disease in 62-65-year-old Subjects

TypeobservationalSponsorVestre Viken Hospital TrustRan2012 to 2050Enrolled3,706ConditionsAtrial Fibrillation, Heart Failure, Mild Cognitive Impairment, Cardiovascular Diseases
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Anupam ChandraDepartment of Renal Medicine, Akershus University Hospital, Sykehusveien 25, 1478, Lørenskog, Norway. Anupam.Chandra@ahus.no.
Helge RøsjøInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ivar Anders EideDepartment of Renal Medicine, Akershus University Hospital, Sykehusveien 25, 1478, Lørenskog, Norway.
Thea VigenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Håkon Ihle-HansenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Eivind Bjørkan OrstadDivision of Medicine, Akershus University Hospital, Lørenskog, Norway.
Ole Morten RønningInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Magnus Nakrem LyngbakkenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Trygve BergeInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Erik Berg SchmidtDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Torbjørn OmlandInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Arnljot TveitInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
My SvenssonDepartment of Renal Medicine, Akershus University Hospital, Sykehusveien 25, 1478, Lørenskog, Norway.
Akershus University Hospital · NOUniversity of Oslo · NOAalborg University Hospital · DKVestre Viken Hospital Trust · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA high intake of marine n-3 polyunsaturated fatty acids (PUFAs) might improve cardiovascular (CV) health. We conducted a cross-sectional study to investigate associations between plasma phospholipid levels of marine n-3 PUFAs and CV risk factors, educational level, physical activity and smoking habits.

methodsA total of 3706 individuals from a general population, all born in 1950 and residing in Akershus County, Norway, were included in this study. The main statistical approach was multivariable adjusted linear regression.

resultsPlasma marine n-3 PUFA levels ranged from 2.7 to 20.3 wt%, with a median level of 7.7 wt% (interquartile range 4.3-11.1 wt%). High levels of plasma marine n-3 PUFAs were associated with lower serum triglycerides [Standardized regression coefficient (Std.β-coeff.) - 0.14, p < 0.001], body mass index (Std. β-coeff. -0.08, p < 0.001), serum creatinine (Std. β-coeff. -0.03, p = 0.05), C-reactive protein levels (Std. β-coeff. - 0.03, p = 0.04), higher levels of serum high-density lipoprotein cholesterol (Std. β-coeff. 0.08, p < 0.001) and low-density lipoprotein cholesterol (Std. β-coeff. 0.04, p = 0.003). High levels of plasma marine n-3 PUFAs were also associated with lower glycated hemoglobin (Std. β-coeff. - 0.04, p = 0.01), however, only in individuals without diabetes. We found no associations between plasma marine n-3 PUFA levels and fasting plasma glucose or carotid intima-media thickness. High levels of plasma marine n-3 PUFAs were associated with higher educational level, more physical activity and lower prevalence of smoking.

conclusionIn this cross-sectional study of Norwegian individuals born in 1950, high levels of plasma marine n-3 PUFAs were favourably associated with several CV risk factors, suggesting that fish consumption might improve CV health.

Indexed as

SeafoodCardiovascular DiseasesCross-Sectional StudiesDietFatty Acids, Omega-3Fatty Acids, UnsaturatedFemaleHealth SurveysHumansMaleMiddle AgedNorwayRisk AssessmentFatty Acids, Omega-3Fatty Acids, UnsaturatedCardiovascular risk factorsDocosahexaenoic acidEicosapentaenoic acidFish consumptionPolyunsaturated fatty acids

Identifiers

PMID31123865
OpenAlexW2945302432

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.