ArticleMikrochimica acta2019
Bimetallic gold/silver nanoclusters as a fluorescent probe for detection of methotrexate and doxorubicin in serum.
Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Spectrophotometric and smartphone-based colorimetric methods utilizing polyvinylpyrrolidone-capped silver nanoparticles for determining doxorubicin in human plasma samples.Scientific reports · 2025Article
- Enzymatically mediated fluorescent copper nanocluster generation for tyramine determination.Analytical and bioanalytical chemistry · 2023Article
- Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer.Pharmaceutics · 2023Review
- Spectrofluorimetric Method for Monitoring Methotrexate in Patients' Plasma Samples and Cell Lysates Using Highly Fluorescent Carbon Dots.Iranian journal of pharmaceutical research : IJPR · 2022Article
- Cerium-doped flower-shaped ZnO nano-crystallites as a sensing component for simultaneous electrochemical determination of epirubicin and methotrexate.Mikrochimica acta · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New bimetallic gold/silver nanoclusters (NCs) are reported that display strong blue fluorescence with excitation/emission maxima at 370/455 nm, decay times of around 14 ns for the main components, and a quantum yield of around 20%. The NCs were synthesized by using L-tryptophan (L-Trp) as the template to react with tetrachloroauric acid and silver nitrate at 120 °C for 4 h in a one-pot reaction. Their fluorescence is around 5 times stronger than that of pure gold nanoclusters. The fluorescence of the bimetallic NCs is strongly reduced in the presence of the antitumor drugs methotrexate (MTX) and doxorubicin (DOX) due to an inner filter effect. Response to MTX is linear in the 2.5-150 μM concentration range, and to DOX in the 2.5-150 μM concentration range. The detection limits are as low as 2.5 nM and 3 nM, respectively. The recoveries from spiked serum are between 87.7% - 101.2% for MTX and between 86.2%-105.4% for DOX. Graphical abstract Schematic presentation of the synthesis of Au/AgNCs and the fluorometric determination of methotrexate (MTX) and doxorubicin (DOX) based on the inner filter effect.
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Registered trials
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