Observational studyDiabetologia2019
Reversion from prediabetes to normoglycaemia and risk of cardiovascular disease and mortality: the Whitehall II cohort study.
Observational study in Diabetologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04511468 (A Combination of Zinc, Chromium, Vitamin C, and Copper Supplement for Prediabetes Progression), which is not on this map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Combination of Zinc, Chromium, Vitamin C, and Copper Supplement for Prediabetes Progression: Randomized Controlled-Trial in Jakarta
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Pharmacological Nephroprotection in Chronic Kidney Disease Patients with Type 2 Diabetes Mellitus-Clinical Practice Position Statement of the Polish Society of Nephrology.International journal of molecular sciences · 2024Guideline
- Outcome of lifestyle intervention in relation to duration of pre-diabetes: the Pathobiology and Reversibility of Prediabetes in a Biracial Cohort (PROP-ABC) study.BMJ open diabetes research & care · 2022Trial
- Article
- Association of creatinine to body weight ratio with glycemic progression and remission in Chinese adults with prediabetes: a large-scale retrospective cohort study.BMC endocrine disorders · 2026Article
- GLP-1 and the cardiovascular system.The Journal of clinical investigation · 2026Review
- A predictive study of glycaemic reversal in Chinese individuals with prediabetes based on machine learning: a 5-year cohort study.Frontiers in endocrinology · 2026Article
- Impact of the longitudinal evolution of impaired fasting glucose on cardio-kidney-metabolic multimorbidity.Frontiers in endocrinology · 2026Article
- Predicting pre-diabetes progression: a systematic review and meta-analysis.BMJ nutrition, prevention & health · 2026Article
- BMI-specific nonlinear associations and threshold effects of the atherogenic index of plasma on incident prediabetes: insights from 100473 Chinese adults.Frontiers in endocrinology · 2026Article
- Epidemiological features and prevalence patterns of prediabetes outcomes in an east coast Malaysian cohort: A retrospective cohort study.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2026Article
- Associations between blood glucose and dynamic plantar pressure distribution in pre-DM patients: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Meal Replacement Provides Additional Benefits for Weight and Visceral Fat Reduction in Prediabetic Individuals: A Randomized Clinical Trial.Journal of nutrition and metabolism · 2026Article
- Pathobiology of Prediabetes: Understanding and Interrupting Progressive Dysglycemia and Associated Complications.Diabetes · 2025Review
- Impact of skeletal muscle mass index on glycemic progression and remission in Chinese adults with prediabetes: a nationwide cohort study.European journal of medical research · 2025Article
- Evolution of prediabetes in an urban cohort of adults living in a Mediterranean area.Nutrition & diabetes · 2025Observational
- The impact of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) on the development of prediabetes in middle-aged and older Chinese adults: a national cohort study.Journal of health, population, and nutrition · 2025Observational
- Joint associations of pre-diabetes, pre-hypertension, and pre-dyslipidemia with cardiovascular and metabolic disease progression.Diabetology & metabolic syndrome · 2025Article
- Factors related to reversal of prediabetes in patients from a cardiovascular risk program during 2019 - 2023.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Longitudinal changes and patterns in cardiometabolic index and the natural course of prediabetes in the China health and retirement longitudinal study.Lipids in health and disease · 2025Article
- The De Ritis ratio mediates the association between creatinine-to-body weight ratio and normoglycemic conversion in Chinese health examinees.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
aims/hypothesisReversion from prediabetes to normoglycaemia is accompanied by an improvement in cardiovascular risk factors, but it is unclear whether this translates into a reduction in risk of cardiovascular disease (CVD) events or death. Hence, we studied the probability of reversion from prediabetes to normoglycaemia and the associated risk of future CVD and death using data from the Whitehall II observational cohort study.
methodsThree glycaemic criteria for prediabetes (fasting plasma glucose [FPG] 5.6-6.9 mmol/l, 2 h plasma glucose [2hPG] 7.8-11.0 mmol/l, and HbA
resultsBased on the FPG criterion, 820 participants had prediabetes and 365 (45%) of them had reverted to normoglycaemia in 5 years. The corresponding numbers were 324 and 120 (37%) for the 2hPG criterion and 1709 and 297 (17%) for the HbA CONCLUSIONS/
interpretationMost people with HbA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.