Evidence map›Paper›PMID 31123771›Full record

ReviewCurrent genetics2019

Moving forward one step back at a time: reversibility during homologous recombination.

Aurèle Piazza, Wolf-Dietrich Heyer

Open access · greenAbstract readReview
In one paragraph

Review in Current genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 53 citations in OpenAlex.

  1. Mechanisms That Govern Recombinase Fidelity Control During Eukaryotic Homologous Recombination.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
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  11. Practical Approaches for the YeastInternational journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Aurèle PiazzaSpatial Regulation of Genomes, Institut Pasteur, CNRS, UMR3525, 28 Rue du Docteur Roux, 75015, Paris, France.
Wolf-Dietrich HeyerDepartment of Microbiology and Molecular Genetics, University of California, Davis, One Shields Ave, Davis, CA, 95616, USA. wdheyer@ucdavis.edu.ORCID http://orcid.org/0000-0002-7774-1953
Centre National de la Recherche Scientifique · FRUniversity of California, Davis · US

Funding

RECOMBINATIONAL MECHANISMS OF DNA REPAIR IN EUKARYOTESR01GM058015 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI HEYER, WOLF-DIETRICH · 2000 to 2025
$8.8M
Regulation of Recombinational DNA RepairR01CA092276 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI HEYER, WOLF-DIETRICH · 2001 to 2020
$5.2M
National Institutes of Health (US) GM58015NCI NIH HHS R01 CA092276NIGMS NIH HHS R01 GM058015NIH HHS CA92776
6 · The paper itself

Abstract

DNA double-strand breaks are genotoxic lesions whose repair can be templated off an intact DNA duplex through the conserved homologous recombination (HR) pathway. Because it mainly consists of a succession of non-covalent associations of molecules, HR is intrinsically reversible. Reversibility serves as an integral property of HR, exploited and tuned at various stages throughout the pathway with anti- and pro-recombinogenic consequences. Here, we focus on the reversibility of displacement loops (D-loops), a central DNA joint molecule intermediate whose dynamics and regulation have recently been physically probed in somatic S. cerevisiae cells. From homology search to repair completion, we discuss putative roles of D-loop reversibility in repair fidelity and outcome.

Indexed as

DNA-Binding ProteinsDNA Breaks, Double-StrandedDNA-Directed DNA PolymeraseDNA HelicasesEndodeoxyribonucleasesRecombinational DNA RepairSaccharomyces cerevisiaeDNA-Binding ProteinsDNA-Directed DNA PolymeraseDNA HelicasesEndodeoxyribonucleasesCrossoverD-loopGenomic stabilityHelicaseHomologous recombinationHomology search

Identifiers

PMID31123771
PMCPMC7027933
OpenAlexW2944852748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.