Evidence map›Paper›PMID 31123718›Full record

ArticleCommunications biology2019

Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B

Jie Yang, Paul Minkler, David Grove, Rui Wang, Belinda Willard, Raed Dweik, Christopher Hine

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 177 citations in OpenAlex.

  1. A universal consuming endogenous HBioactive materials · 2027
    Article
  2. Elemental analysis in menstrual effluent of women with PCOS: association with oxidative stress mechanisms: a case-control study.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
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  5. Review
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  11. Hydrogen Sulfide Signaling in Neurodegenerative Movement Disorders.Handbook of experimental pharmacology · 2026
    Review
  12. Crosstalk Between HHandbook of experimental pharmacology · 2026
    Review
  13. HFrontiers in cell and developmental biology · 2026
    Review
  14. Cystathionine γ-lyase is a major regulator of cognitive function through neurotrophin signaling and neurogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Targeting macro- and micro-nutrient regulation of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  16. Black gas, bright future: HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  17. Intersection of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  18. Review
  19. Brassinin Induces HMolecules (Basel, Switzerland) · 2025
    Article
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jie Yang1Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195 USA.
Paul Minkler2Proteomics and Metabolomics Core, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195 USA.
David Grove3Department of Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195 USA.
Rui Wang4Faculty of Science, Department of Biology, York University, Toronto, Canada M3J 1P3.
Belinda Willard2Proteomics and Metabolomics Core, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195 USA.
Raed Dweik5Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195 USA.
Christopher Hine1Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195 USA.ORCID 0000-0003-1926-7939
Cleveland Clinic Lerner College of Medicine · USCleveland Clinic · USYork University · CA

Funding

Requirement of hydrogen sulfide for the benefits of dietary sulfur amino acid restrictionR00AG050777 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI HINE, CHRISTOPHER MICHAEL · 2017 to 2019
$747k
NIA NIH HHS R00 AG050777
6 · The paper itself

Abstract

Hydrogen sulfide (H

Indexed as

AnimalsCatalysisCysteineErythrocytesHemolysisHydrogen SulfideHydrolysisIronMaleMiceMice, Inbred C57BLMice, KnockoutPyridoxal PhosphateSpectrophotometry, UltravioletVitamin B 6CysteineHydrogen SulfideIronPyridoxal PhosphateVitamin B 6BiochemistryHaematological diseasesPhysiology

Identifiers

PMID31123718
PMCPMC6529520
OpenAlexW2945159151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.