Evidence map›Paper›PMID 31123687›Full record

ArticleJournal of biological methods2019

Multi-parametric flow cytometry staining procedure for analyzing tumor-infiltrating immune cells following oncolytic herpes simplex virus immunotherapy in intracranial glioblastoma.

Praveen K Bommareddy, Devin B Lowe, Howard L Kaufman, Samuel D Rabkin, Dipongkor Saha

Open access · diamondAbstract read
In one paragraph

Article in Journal of biological methods, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Praveen K BommareddySchool of Graduate Studies, Rutgers University, New Brunswick, NJ 08901, USA.
Devin B LoweDepartment of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX 79601, USA.
Howard L KaufmanDivision of Surgical Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
Samuel D RabkinMolecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Dipongkor SahaDepartment of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX 79601, USA.
Massachusetts General Hospital · USTexas Tech University · USRutgers Sexual and Reproductive Health and Rights · NL

Funding

Targeting Tumorigenic Pathways in Glioblastoma with Oncolytic HSVR01CA160762 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI RABKIN, SAMUEL DAVID · 2012 to 2023
$3.7M
Immunotherapeutic targeting of colon cancer vascularization to achieve long-term protective immunityR15CA215874 · NCI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI LOWE, DEVIN B · 2018 to 2018
$453k
NCI NIH HHS R01 CA160762NCI NIH HHS R15 CA215874
6 · The paper itself

Abstract

Multi-color flow cytometry is a standard laboratory protocol, which is regularly used to analyze tumor-infiltrating immune cell subsets. Oncolytic herpes simplex virus has shown promise in treating various types of cancers, including deadly glioblastoma. Intracranial/intratumoral treatment with oncolytic herpes simplex virus expressing interleukin 12,

Indexed as

flow cytometryglioblastomaimmune cellsimmunovirotherapyoncolytic herpes simplex virus

Identifiers

PMID31123687
PMCPMC6528664
OpenAlexW2933495226

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.