Evidence map›Paper›PMID 31123668›Full record

ArticleAdvanced biomedical research2019

Comparative Effect of Intravenous Ketamine and Electroconvulsive Therapy in Major Depression: A Randomized Controlled Trial.

Gholamreza Kheirabadi, Maryam Vafaie, Dorna Kheirabadi, Zahra Mirlouhi, Rasam Hajiannasab

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Article in Advanced biomedical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 6 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gholamreza KheirabadiDepartment of Psychiatry, School of Medicine, Behavioral Sciences Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
Maryam VafaieDepartment of Psychiatry, School of Medicine, Behavioral Sciences Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
Dorna KheirabadiDepartment of psychiatry, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Zahra MirlouhiDepartment of Psychiatry, School of Medicine, Behavioral Sciences Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
Rasam HajiannasabSchool of Medicine, Azad University of Iran, Najafabad Unite, Najafabad, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAchieving a rapid onset and durable methods of treatment for major depressive disorders is an issue pursuing in psychiatry. This study was designed to assess the therapeutic efficacy of intravenous (IV) ketamine injection in controlling depressive symptoms in comparison with electroconvulsive therapy (ECT) in major depressed disordered patients. MATERIALS AND

methodsThirty-two patients over 18 years of age who were candidates for ECT were enrolled in the study. They were allocated into two groups using block design randomization. Sixteen patients received IV infusion of 0.5-mg/kg ketamine and 16 patients underwent a bitemporal ECT. To evaluate the changes in depression severity, researchers administered Hamilton Depression Rating Scale (HDRS) at baseline, before each treatment session, and four time points posttreatment (week 1 and months 1, 2, and 3). The Wechsler Memory Scale was used to evaluate the cognitive state of patients in week 1, month 1, and month 3 of the treatment.

resultsThe HDRS showed improvement in depressive symptoms in both the groups with no statistically significant difference. Cognitive state was more favorable (but not significant) in the ketamine group (

conclusionTreatment with IV ketamine in depressed people has the same antidepressant effects as ECT treatment without any memory deficiency.

Indexed as

Depressionelectroconvulsive therapyketamine

Identifiers

PMID31123668
PMCPMC6477832

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.