Evidence map›Paper›PMID 31123578›Full record

ArticleChemical science2019

Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene.

David R Chisholm, Rebecca Lamb, Tommy Pallett, Valerie Affleck, Claire Holden, Joanne Marrison, Peter O'Toole, Peter D Ashton, Katherine Newling, Andreas Steffen and 9 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Pharmaceutics · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 4 countries.

David R ChisholmDepartment of Chemistry , Durham University , Science Laboratories , South Road , Durham DH1 3LE , UK . Email: andy.whiting@durham.ac.uk.
Rebecca LambDepartment of Biosciences , Durham University , South Road , Durham, DH1 3LE , UK.
Tommy PallettDepartment of Biosciences , Durham University , South Road , Durham, DH1 3LE , UK.
Valerie AffleckLightOx Limited , Wynyard Park House , Wynyard Avenue, Wynyard , Billingham , TS22 5TB , UK.
Claire HoldenDepartment of Chemistry , Durham University , Science Laboratories , South Road , Durham DH1 3LE , UK . Email: andy.whiting@durham.ac.uk.
Joanne MarrisonBioscience Technology Facility , Department of Biology , University of York , York , YO10 5DD , UK.
Peter O'TooleBioscience Technology Facility , Department of Biology , University of York , York , YO10 5DD , UK.
Peter D AshtonBioscience Technology Facility , Department of Biology , University of York , York , YO10 5DD , UK.
Katherine NewlingBioscience Technology Facility , Department of Biology , University of York , York , YO10 5DD , UK.
Andreas SteffenInstitut für Anorganische Chemie , Julius-Maximilians-Universität Würzburg , Am Hubland , 97074 Würzburg , Germany.
Amanda K NelsonInstitut für Anorganische Chemie , Julius-Maximilians-Universität Würzburg , Am Hubland , 97074 Würzburg , Germany.
Christoph MahlerInstitut für Anorganische Chemie , Julius-Maximilians-Universität Würzburg , Am Hubland , 97074 Würzburg , Germany.
Roy ValentineHigh Force Research Ltd. , Bowburn North Industrial Estate , Bowburn , Durham , DH6 5PF , UK.
Thomas S BlackerDepartment of Physics & Astronomy , University College London , Gower Street , London , WC1E 6BT , UK.
Angus J BainDepartment of Physics & Astronomy , University College London , Gower Street , London , WC1E 6BT , UK.ORCID 0000-0001-8705-8536
John GirkinBiophysical Sciences Institute , Department of Physics , Durham University , South Road , Durham , DH1 3LE , UK.ORCID 0000-0003-2568-3576
Todd B MarderInstitut für Anorganische Chemie , Julius-Maximilians-Universität Würzburg , Am Hubland , 97074 Würzburg , Germany.ORCID 0000-0002-9990-0169
Andrew WhitingDepartment of Chemistry , Durham University , Science Laboratories , South Road , Durham DH1 3LE , UK . Email: andy.whiting@durham.ac.uk.ORCID 0000-0001-8937-8445
Carrie A AmblerDepartment of Biosciences , Durham University , South Road , Durham, DH1 3LE , UK.ORCID 0000-0002-2697-7376
Durham University · GBUniversity of Würzburg · DEUniversity of York · GBTransnational Press LondonDurham Technical Community College · USLoxo Oncology at Lilly (United States) · US

Funding

Medical Research Council MC_PC_18045
6 · The paper itself

Abstract

Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified by

Identifiers

PMID31123578
PMCPMC6495688
OpenAlexW2923361491

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.