SynthesisThe western journal of emergency medicine2019
Mortality and Thrombosis in Injured Adults Receiving Tranexamic Acid in the Post-CRASH-2 Era.
Synthesis in The western journal of emergency medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Tranexamic acid in radical cystectomy: a systematic review and meta-analysis of efficacy and safety.World journal of urology · 2025Pooled it
- Tranexamic Acid in Body Contouring Surgery: A Systematic Review and Meta-Analysis.Aesthetic surgery journal · 2025Pooled it
- Tranexamic acid in radical cystectomy: a systematic review and meta-analysis.Surgery in practice and science · 2026Review
- Unraveling the neurotoxic mechanisms of tranexamic acid in epilepsy induction: a network toxicology and molecular docking approach.BMC medicine · 2026Article
- High-Dose Tranexamic Acid Enhances Circulating Neutrophil Extracellular Traps and Thrombus in Thrombosis Mouse Model.Biomedicines · 2025Article
- Safety and efficacy of tranexamic acid in radical cystectomy: a systematic review and meta-analysis.Central European journal of urology · 2025Review
- Perioperative anesthesia management of high-molecular-weight kininogen deficiency: a case report and literature review.Frontiers in medicine · 2025Article
- Does tranexamic acid have a positive effect on the outcome of older multiple trauma patients on antithrombotic drugs? An analysis using the TraumaRegister DGUFrontiers in medicine · 2024Article
- The impact of tranexamic acid on perioperative outcomes in urological surgeries A systematic review and meta-analysis.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2023Review
- Emergency Blood Transfusion for Trauma and Perioperative Resuscitation: Standard of Care.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2021Review
- Functional testing of tranexamic acid effects in patients undergoing elective orthopaedic surgery.Journal of thrombosis and thrombolysis · 2021Observational
- The many roles of tranexamic acid: An overview of the clinical indications for TXA in medical and surgical patients.European journal of haematology · 2020Review
- Impact of a goal-directed factor-based coagulation management on thromboembolic events following major trauma.Scandinavian journal of trauma, resuscitation and emergency medicine · 2019Observational
- Clinical use of tranexamic acid: evidences and controversies.Brazilian journal of anesthesiology (Elsevier)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe CRASH-2 trial demonstrated that tranexamic acid (TXA) reduced mortality with no increase in adverse events in severely injured adults. TXA has since been widely used in injured adults worldwide. Our objective was to estimate mortality and adverse events in adults with trauma receiving TXA in studies published after the CRASH-2 trial.
methodsWe systematically searched PubMed, Embase, MicroMedex, and ClinicalTrials.gov for studies that included injured adults who received TXA and reported mortality and/or adverse events. Two reviewers independently assessed study eligibility, abstracted data, and assessed the risk of bias. We conducted meta-analyses using random effects models to estimate the incidence of mortality at 28 or 30 days and in-hospital thrombotic events.
resultsWe included 19 studies and 13 studies in the systematic review and meta-analyses, respectively. The pooled incidence of mortality at 28 or 30 days (five studies, 1538 patients) was 10.1% (95% confidence interval [CI], 7.8-12.4%) (vs 14.5% [95% CI, 13.9-15.2%] in the CRASH-2 trial), and the pooled incidence of in-hospital thrombotic events (nine studies, 1656 patients) was 5.9% (95% CI, 3.3-8.5%) (vs 2.0% [95% CI, 1.8-2.3%] in the CRASH-2 trial).
conclusionCompared to the CRASH-2 trial, adult trauma patients receiving TXA identified in our systematic review had a lower incidence of mortality at 28 or 30 days, but a higher incidence of in-hospital thrombotic events. Our findings neither support nor refute the findings of the CRASH-2 trial but suggest that incidence rates in adults with trauma in settings outside of the CRASH-2 trial may be different than those observed in the CRASH-2 trial.
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