Evidence map›Paper›PMID 31123328›Full record

ArticleScientific reports2019

Multi-omics Analysis of Liver Infiltrating Macrophages Following Ethanol Consumption.

John O Marentette, Meng Wang, Cole R Michel, Roger Powell, Xing Zhang, Nichole Reisdorph, Kristofer S Fritz, Cynthia Ju

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

John O MarentetteSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Meng WangSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Cole R MichelSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Roger PowellSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Xing ZhangSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Nichole ReisdorphSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Kristofer S FritzSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. Kristofer.Fritz@ucdenver.edu.
Cynthia JuSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. Changqing.Ju@uth.tmc.edu.
University of Colorado Anschutz Medical Campus · US

Funding

Role of Eosinophils in Hepatic Ischemia Reperfusion InjuryR01DK121330 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Cynthia Ju · 2019 to 2026
$3.3M
Ethanol-induced Protein Acylation Regulates MetabolismR01AA022146 · NIAAA · DUKE UNIVERSITY · PI FRITZ, KRISTOFER S, HIRSCHEY, MATTHEW D · 2013 to 2017
$2.3M
Role of Bone Marrow-Derived Myeloid Cells in Alcohol Liver DiseaseU01AA021723 · NIAAA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI JU, CYNTHIA · 2013 to 2017
$1.6M
Role of gp91phox in Hepatic MF Programming and Alcohol Liver DiseaseR21AA024636 · NIAAA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI JU, CYNTHIA · 2016 to 2017
$406k
NIAAA NIH HHS R01 AA022146NIAAA NIH HHS R21 AA024636NIAAA NIH HHS U01 AA021723NIDDK NIH HHS R01 DK121330U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) R01DK10957
6 · The paper itself

Abstract

Alcoholic liver disease (ALD) is a significant health hazard and economic burden affecting approximately 10 million people in the United States. ALD stems from the production of toxic-reactive metabolites, oxidative stress and fat accumulation in hepatocytes which ultimately results in hepatocyte death promoting hepatitis and fibrosis deposition. Monocyte-derived infiltrating Ly6C

Indexed as

Alcohol DrinkingAnimalsComputational BiologyEthanolLiverLiver Diseases, AlcoholicMacrophagesMiceOxidative StressProteomicsEthanol

Identifiers

PMID31123328
PMCPMC6533323
OpenAlexW2946165892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.