ArticleScientific reports2019
Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Developmental differences in threat learning are associated with changes in frontal-central theta activity.European child & adolescent psychiatry · 2025Article
- Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology.Development and psychopathology · 2025Article
- The beautiful adolescent brain: An evolutionary developmental perspective.Annals of the New York Academy of Sciences · 2025Review
- Fear extinction retention in children, adolescents, and adults.Developmental cognitive neuroscience · 2025Article
- Article
- Getting Better with Age? A Review of Psychophysiological Studies of Fear Extinction Learning Across Development.Current topics in behavioral neurosciences · 2023Review
- Neurodevelopmental mechanisms linking early experiences and mental health: Translating science to promote well-being among youth.The American psychologist · 2022Article
- High vagal tone and rapid extinction learning as potential transdiagnostic protective factors following childhood violence exposure.Developmental psychobiology · 2021Article
- Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders - A preliminary study.Behavioural brain research · 2021Article
- Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain.The American journal of psychiatry · 2021Review
- Adolescent anxiety disorders and the developing brain: comparing neuroimaging findings in adolescents and adults.General psychiatry · 2021Review
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Authors and funding
3 authors.
Funding
Abstract
Previous research in rodents and humans points to an evolutionarily conserved profile of blunted threat extinction learning during adolescence, underpinned by brain structures such as the amygdala and medial prefrontal cortex (mPFC). In this study, we examine age-related effects on the function and structural connectivity of this system in threat extinction learning in adolescence and young adulthood. Younger age was associated with greater amygdala activity and later engagement of the mPFC to learned threat cues as compared to safety cues. Furthermore, greater structural integrity of the uncinate fasciculus, a white matter tract that connects the amygdala and mPFC, mediated the relationship between age and mPFC engagement during extinction learning. These findings suggest that age-related changes in the structure and function of amygdala-mPFC circuitry may underlie the protracted maturation of threat regulatory processes.
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Registered trials
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