Evidence map›Paper›PMID 31123248›Full record

ArticleTranslational psychiatry2019

Genetic variant in SLC1A2 is associated with elevated anterior cingulate cortex glutamate and lifetime history of rapid cycling.

Marin Veldic, Vincent Millischer, John D Port, Ada Man-Choi Ho, Yun-Fang Jia, Jennifer R Geske, Joanna M Biernacka, Lena Backlund, Susan L McElroy, David J Bond and 6 more

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Journal of personalized medicine · 2023
    Article
  6. Astrocyte regulation of synaptic signaling in psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Review
  7. Article
  8. Association Study of theJournal of clinical medicine · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Marin VeldicDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA. Veldic.Marin@mayo.edu.
Vincent MillischerDepartment of Molecular Medicine and Surgery (MMK), Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-1919-9649
John D PortDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-4237-7776
Ada Man-Choi HoDepartment of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-4989-8782
Yun-Fang JiaDepartment of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Jennifer R GeskeDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Joanna M BiernackaDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-9350-4440
Lena BacklundDepartment of Molecular Medicine and Surgery (MMK), Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-9399-5024
Susan L McElroyLindner Center of Hope, University of Cincinnati, Cincinnati, OH, USA.
David J BondDepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
J Carlos VillaescusaDepartment of Molecular Medicine and Surgery (MMK), Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-9456-9828
Michelle SkimeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Doo-Sup ChoiDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Catharina LavebrattDepartment of Molecular Medicine and Surgery (MMK), Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-4987-2718
Martin SchallingDepartment of Molecular Medicine and Surgery (MMK), Karolinska Institutet, Stockholm, Sweden.
Mark A FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic · USKarolinska University Hospital · SELindner Center of HOPE · USMayo Clinic in Arizona · USMayo Clinic in Florida · USUniversity of Minnesota · US

Funding

1H-MR Spectroscopy of Bipolar Depression Before and After Lamotrigine TreatmentR01MH079261 · NIMH · MAYO CLINIC ROCHESTER · PI FRYE, MARK A · 2009 to 2013
$1.2M
NIMH NIH HHS R01 MH079261
6 · The paper itself

Abstract

Glutamatergic dysregulation is implicated in the neurobiology of mood disorders. This study investigated the relationship between the anterior cingulate cortex (AC) glutamate, as measured by proton magnetic resonance spectroscopy (

Indexed as

Bipolar DisorderMajor Depressive DisorderAdultCohort StudiesExcitatory Amino Acid Transporter 2FemaleGlutamic AcidGyrus CinguliHumansHyaluronan ReceptorsMaleMiddle AgedPolymorphism, Single NucleotideProton Magnetic Resonance SpectroscopyCD44 protein, humanExcitatory Amino Acid Transporter 2Glutamic AcidHyaluronan ReceptorsSLC1A2 protein, human

Identifiers

PMID31123248
PMCPMC6533282
OpenAlexW2945865979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.