Evidence map›Paper›PMID 31123156›Full record

ArticleDiabetes care2019

Utility of Plasma Concentration of Trimethylamine N-Oxide in Predicting Cardiovascular and Renal Complications in Individuals With Type 1 Diabetes.

Signe A Winther, Jens C Øllgaard, Nete Tofte, Lise Tarnow, Zeneng Wang, Tarunveer S Ahluwalia, Anders Jorsal, Simone Theilade, Hans-Henrik Parving, Tine W Hansen and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 7 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 7 syntheses or guidelines pooled it, 110 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Signe A WintherSteno Diabetes Center Copenhagen, Gentofte, Denmark signe.abitz.winther@regionh.dk.ORCID 0000-0001-7949-0193
Jens C ØllgaardSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Nete TofteSteno Diabetes Center Copenhagen, Gentofte, Denmark.ORCID 0000-0002-5331-9168
Lise TarnowSteno Diabetes Center Zealand, Holbaek, Denmark.
Zeneng WangLerner Research Institute and Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH.
Tarunveer S AhluwaliaSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Anders JorsalDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Simone TheiladeSteno Diabetes Center Copenhagen, Gentofte, Denmark.ORCID 0000-0002-1151-8951
Hans-Henrik ParvingDepartment of Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Tine W HansenSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Stanley L HazenLerner Research Institute and Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Peter RossingSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Steno Diabetes Centers · DKUniversity of Copenhagen · DKCleveland Clinic Lerner College of Medicine · USAarhus University Hospital · DK

Funding

Gut Flora Metabolism of Dietary Phosphatidylcholine and CVDR01HL103866 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2010 to 2023
$10.8M
Diet, Gut Microbiota, and Heart FailureR01HL126827 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L, TANG, WAI HONG WILSON · 2016 to 2019
$3.1M
Dietary Choline, Gut Microbiota, and Susceptibility for Chronic Kidney DiseaseR01DK106000 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L, TANG, WAI HONG WILSON · 2015 to 2018
$2.8M
NHLBI NIH HHS R01 HL103866NHLBI NIH HHS R01 HL126827NIDDK NIH HHS R01 DK106000
6 · The paper itself

Abstract

objectiveTrimethylamine N-oxide (TMAO) is suggested as an independent gut microbiota-derived risk factor for cardiovascular and renal disease. We investigated associations between plasma TMAO concentrations and cardio-renal outcomes in a prospective study of individuals with type 1 diabetes. RESEARCH DESIGN AND

methodsPlasma TMAO was measured at baseline in 1,159 individuals with type 1 diabetes (58% male, mean ± SD age 46 ± 13 years). End points were all-cause and cardiovascular mortality, cardiovascular disease (CVD), and renal events tracked from national registries. Associations between TMAO and end points were tested using Cox regression models.

resultsAfter 15.0 (6.7-19.3) (median [interquartile range]) years of follow-up, we recorded all-cause and cardiovascular mortality (

conclusionsIn individuals with type 1 diabetes, higher concentrations of plasma TMAO were associated with mortality, CVD events, and poor renal outcome, independent of conventional risk factors. However, the association became insignificant after further adjustment for baseline eGFR. This could reflect TMAO as a renal function marker or a risk factor for micro- and macrovascular complications mediated through impaired renal function.

Indexed as

AgedBiomarkersDiabetes Mellitus, Type 1Diabetic CardiomyopathiesDiabetic NephropathiesFemaleGastrointestinal MicrobiomeGlomerular Filtration RateHumansKidneyKidney Failure, ChronicMaleMethylaminesMiddle AgedMyocardial InfarctionProportional Hazards ModelsBiomarkersMethylaminestrimethyloxamine

Identifiers

PMID31123156
PMCPMC7082641
OpenAlexW2945243141

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.