ArticleJournal of neurology, neurosurgery, and psychiatry2019
Thalamic arousal network disturbances in temporal lobe epilepsy and improvement after surgery.
Article in Journal of neurology, neurosurgery, and psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness.Frontiers in neurology · 2025Pooled it
- Disrupted thalamic functional hierarchy on resting-state fMRI in idiopathic generalized epilepsy.European radiology experimental · 2026Article
- Cause, Consequence, or Compass? The Thalamus in Temporal Lobe Epilepsy Surgery.Epilepsy currents · 2026Article
- Nucleus basalis functional connectivity aberrations in temporal lobe epilepsy and improvements after successful epilepsy surgery.Epilepsia · 2026Article
- Thalamic connectivity mirrors spatial maps of network dysfunction in nonlesional focal epilepsy.Epilepsia · 2026Article
- Article
- Neuroimmune activation in temporal lobe epilepsy patients with worsening seizure following the COVID-19 pandemic: A [Science advances · 2026Article
- The bed nucleus of the stria terminalis as a neuromodulatory target for refractory epilepsy.Frontiers in network physiology · 2026Review
- High energy consumption characterizes abnormal brain state transitions in temporal lobe epilepsy.Neurobiology of disease · 2025Article
- Thalamic neural activity and epileptic network analysis using stereoelectroencephalography: a prospective study protocol.BMJ open · 2025Article
- The impact of resective epilepsy surgery on the brain network: evidence from post-surgical imaging.Brain : a journal of neurology · 2025Review
- Impact of disease duration and surgical intervention on arousal networks in temporal lobe epilepsy.Journal of neurosurgery · 2025Article
- Thalamic Volumes and Functional Networks Linked With Self-Regulation Dysfunction in Major Depressive Disorder.CNS neuroscience & therapeutics · 2024Article
- Graph Theory and Modeling of Network Topology in Clinical Neurosurgery.Advances in experimental medicine and biology · 2024Review
- Differences in whole-brain metabolism are associated with the expression of genes related to neurovascular unit integrity and synaptic plasticity in temporal lobe epilepsy.European journal of nuclear medicine and molecular imaging · 2023Article
- Connectivity alteration in thalamic nuclei and default mode network-related area in memory processes in mesial temporal lobe epilepsy using magnetoencephalography.Scientific reports · 2023Article
- Arousal and salience network connectivity alterations in surgical temporal lobe epilepsy.Journal of neurosurgery · 2023Article
- Profiles of resting state functional connectivity in temporal lobe epilepsy associated with post-laser interstitial thermal therapy seizure outcomes and semiologies.Frontiers in neuroimaging · 2023Article
- Altered Resting State Networks Before and After Temporal Lobe Epilepsy Surgery.Brain topography · 2022Article
- Classification of partial seizures based on functional connectivity: A MEG study with support vector machine.Frontiers in neuroinformatics · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
objectiveThe effects of temporal lobe epilepsy (TLE) on subcortical arousal structures remain incompletely understood. Here, we evaluate thalamic arousal network functional connectivity in TLE and examine changes after epilepsy surgery.
methodsWe examined 26 adult patients with TLE and 26 matched control participants and used resting-state functional MRI (fMRI) to measure functional connectivity between the thalamus (entire thalamus and 19 bilateral thalamic nuclei) and both neocortex and brainstem ascending reticular activating system (ARAS) nuclei. Postoperative imaging was completed for 19 patients >1 year after surgery and compared with preoperative baseline.
resultsBefore surgery, patients with TLE demonstrated abnormal thalamo-occipital functional connectivity, losing the normal negative fMRI correlation between the intralaminar central lateral (CL) nucleus and medial occipital lobe seen in controls (p < 0.001, paired t-test). Patients also had abnormal connectivity between ARAS and CL, lower ipsilateral intrathalamic connectivity, and smaller ipsilateral thalamic volume compared with controls (p < 0.05 for each, paired t-tests). Abnormal brainstem-thalamic connectivity was associated with impaired visuospatial attention (ρ = -0.50, p = 0.02, Spearman's rho) while lower intrathalamic connectivity and volume were related to higher frequency of consciousness-sparing seizures (p < 0.02, Spearman's rho). After epilepsy surgery, patients with improved seizures showed partial recovery of thalamo-occipital and brainstem-thalamic connectivity, with values more closely resembling controls (p < 0.01 for each, analysis of variance).
conclusionsOverall, patients with TLE demonstrate impaired connectivity in thalamic arousal networks that may be involved in visuospatial attention, but these disturbances may partially recover after successful epilepsy surgery. Thalamic arousal network dysfunction may contribute to morbidity in TLE.
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