Evidence map›Paper›PMID 31123136›Full record

ArticleScience (New York, N.Y.)2019

Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases.

Miles H Black, Adam Osinski, Marcin Gradowski, Kelly A Servage, Krzysztof Pawłowski, Diana R Tomchick, Vincent S Tagliabracci

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
16.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 150 citations in OpenAlex.

  1. Crystal structure of theVirulence · 2026
    Article
  2. Review
  3. PHLPP is neither a Phosphatase nor a Tumor Suppressor.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  4. Article
  5. Review
  6. TIR-like NADases act in bacterial immunity and the RNA vault.bioRxiv : the preprint server for biology · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Molecular evolution and adaptations ofFrontiers in cellular and infection microbiology · 2026
    Review
  12. Article
  13. Review
  14. Review
  15. Crystal structure of thebioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Miles H BlackDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-2864-1710
Adam OsinskiDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-0010-0733
Marcin GradowskiWarsaw University of Life Sciences, Warsaw, Poland.ORCID 0000-0001-7695-5434
Kelly A ServageDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-7183-2865
Krzysztof PawłowskiWarsaw University of Life Sciences, Warsaw, Poland.ORCID 0000-0002-5367-0935
Diana R TomchickDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Vincent S TagliabracciDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. vincent.tagliabracci@utsouthwestern.edu.ORCID 0000-0002-9735-4678
The University of Texas Southwestern Medical Center · USWarsaw University of Life Sciences · PLHoward Hughes Medical Institute · US

Funding

Breathing life into dead enzymesDP2GM137419 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI TAGLIABRACCI, VINCENT SCOTT · 2019 to 2020
$2.6M
Phosphorylation of FGF23 coordinates crosstalk between the skeleton and kidneyR00DK099254 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI TAGLIABRACCI, VINCENT SCOTT · 2015 to 2017
$746k
Single Crystal X-ray Diffractometer equipped with Hybrid Pixel Array Detector and In Situ Crystallization Plate Screening CapS10OD025018 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI TOMCHICK, DIANA R. · 2018 to 2018
$453k
Lipoprotein Phosphorylation by Secretory Pathway KinasesF30HL143859 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI BLACK, MILES HENRY · 2018 to 2021
$102k
NHLBI NIH HHS F30 HL143859NIDDK NIH HHS R00 DK099254NIGMS NIH HHS DP2 GM137419NIH HHS S10 OD025018
6 · The paper itself

Abstract

Enzymes with a protein kinase fold transfer phosphate from adenosine 5'-triphosphate (ATP) to substrates in a process known as phosphorylation. Here, we show that the

Indexed as

UbiquitinationBacterial ProteinsBiocatalysisCalmodulinCatalytic DomainCrystallography, X-RayHEK293 CellsHumansLegionella pneumophilaPhosphorylationPolyglutamic AcidProtein DomainsProtein KinasesUbiquitin-Protein LigasesVirulence FactorsBacterial ProteinsCalmodulinPolyglutamic AcidProtein KinasesSidJ protein, Legionella pneumophilaUbiquitin-Protein LigasesVirulence Factors

Identifiers

PMID31123136
PMCPMC6767918
OpenAlexW2945860513

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.