Evidence map›Paper›PMID 31123107›Full record

ArticleMolecular & cellular proteomics : MCP2019

Proteomic Analysis of Vocal Fold Fibroblasts Exposed to Cigarette Smoke Extract: Exploring the Pathophysiology of Reinke's Edema.

Markus Gugatschka, Barbara Darnhofer, Tanja Grossmann, Matthias Schittmayer, David Hortobagyi, Andrijana Kirsch, Eva Karpf, Luka Brcic, Ruth Birner-Gruenberger, Michael Karbiener

Open access · hybridAbstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Increased matrix metalloproteinase-1 expression by coexposure to UVA and cigarette sidestream smoke and contribution of histone acetylation.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025
    Article
  3. The Effect of Oxidative Stress on the Human Voice.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Phonosurgery of Reinke's edema with microdebrider.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Article
  8. Reinke's edema management and voice outcomes.Laryngoscope investigative otolaryngology · 2022
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. DNA rare copy number alterations in Reinke's Edema.Brazilian journal of otorhinolaryngology
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Markus Gugatschka‡Division of Phoniatrics, Medical University of Graz, Graz, Austria. Electronic address: markus.gugatschka@medunigraz.at.
Barbara Darnhofer¶Omics Center Graz, BioTechMed-Graz, Graz, Austria; ‖Austrian Center of Industrial Biotechnology, Graz, Austria.
Tanja Grossmann‡Division of Phoniatrics, Medical University of Graz, Graz, Austria.
Matthias Schittmayer§Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria; ¶Omics Center Graz, BioTechMed-Graz, Graz, Austria; ‖Austrian Center of Industrial Biotechnology, Graz, Austria.
David Hortobagyi‡Division of Phoniatrics, Medical University of Graz, Graz, Austria.
Andrijana Kirsch‡Division of Phoniatrics, Medical University of Graz, Graz, Austria.
Eva Karpf**Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.
Luka Brcic**Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.
Ruth Birner-Gruenberger§Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria; ¶Omics Center Graz, BioTechMed-Graz, Graz, Austria; ‖Austrian Center of Industrial Biotechnology, Graz, Austria; **Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.
Michael Karbiener‡Division of Phoniatrics, Medical University of Graz, Graz, Austria; §§Takeda, Vienna, Austria.
Medical University of Graz · ATBioTechMed-Graz · AT

Funding

Austrian Science Fund FWF P 30496
6 · The paper itself

Abstract

Reinke's edema is a smoking-associated, benign, mostly bilateral lesion of the vocal folds leading to difficulties in breathing and voice problems. Pronounced histological changes such as damaged microvessels or immune cell infiltration have been described in the vocal fold connective tissue, the

Indexed as

Cigarette SmokingSmokeCells, CulturedEdemaFibroblastsHumansLaryngeal DiseasesProteomicsVocal CordsSmokeCigarette smokeClinical proteomicsExtracellular matrix*InflammationLarynxOxidative stressProtein Identification*Reinke's edemaVocal fold fibroblasts

Identifiers

PMID31123107
PMCPMC6683006
OpenAlexW2945937329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.