Trial reportArchives of disease in childhood. Fetal and neonatal edition2020
Physiological effects of high-flow nasal cannula therapy in preterm infants.
Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- [Efficacy of high-flow nasal cannula versus nasal continuous positive airway pressure in the treatment of respiratory distress syndrome in neonates: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Pooled it
- Weaning strategies for the withdrawal of non-invasive respiratory support applying continuous positive airway pressure in preterm infants: a systematic review and meta-analysis.BMJ paediatrics open · 2020Pooled it
- Changes in lung aeration with high-flow nasal cannula compared to nasal CPAP in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Trial
- Pre-oxygenation with high-flow oxygen through the nasopharyngeal airway compared to facemask on carbon dioxide clearance in emergency adults: a prospective randomized non-blinded clinical trial.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Trial
- CPAP and high-flow nasal oxygen also reduce lung, diaphragm, and accessory muscle injury in experimental self-inflicted lung injury.Scientific reports · 2026Article
- Review
- Salivary cortisol is not associated with dexamethasone response in preterm infants with evolving bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2026Observational
- Feeding practices during high-flow nasal cannula: current evidence and clinical implications for respiratory care.Frontiers in nutrition · 2026Review
- Evaluating Clinically Directed Continuous Positive Airway Pressure to High Flow Nasal Cannula Transitions in Stable Preterm Infants Using Electrical Impedance Tomography: A Prospective, Observational Study.Pediatric pulmonology · 2025Observational
- Application of the 2023 Italian guidelines for respiratory support management in acute viral bronchiolitis: a retrospective study.BMJ paediatrics open · 2025Observational
- Impact of Kangaroo Mother Care on Physiological Parameters and Health Experiences of Primiparous Mothers at a Tertiary Care Center: A Mixed-Methods Study.Journal of pharmacy & bioallied sciences · 2025Article
- Feeding Infants on Noninvasive Respiratory Support: Practice at One Academic Medical Center.American journal of speech-language pathology · 2025Article
- Lung Volume Changes in Stable Preterm Infants Weaned From Nasal CPAP to High Flow: A Prospective Cohort Study.CHEST pulmonary · 2024Article
- Feasibility and safety of weaning premature infants from nasal continuous positive airway pressure to high-flow nasal cannula: a prospective observational case study.BMC pediatrics · 2024Observational
- Evaluating Pressure Variability and Influencing Factors during High-Flow Nasal Cannula Therapy in Premature Infants.Children (Basel, Switzerland) · 2024Article
- Respiratory Support Effects over Time on Regional Lung Ventilation Assessed by Electrical Impedance Tomography in Premature Infants.Medicina (Kaunas, Lithuania) · 2024Article
- The effects of flow settings during high-flow nasal cannula oxygen therapy for neonates and young children.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Changes in the patterns of respiratory support and incidence of bronchopulmonary dysplasia; a single center experience.BMC pediatrics · 2023Article
- Nasal high flow therapy for primary respiratory support in preterm infants.The Cochrane database of systematic reviews · 2023Review
- Reducing the time delay of oxygen transport to the neonate on continuous positive airway pressure support: A bench study.Frontiers in pediatrics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveHigh-flow nasal cannula (HFNC) therapy is increasingly used in preterm infants despite a paucity of physiological studies. We aimed to investigate the effects of HFNC on respiratory physiology. STUDY
designA prospective randomised crossover study was performed enrolling clinically stable preterm infants receiving either HFNC or nasal continuous positive airway pressure (nCPAP). Infants in three current weight groups were studied: <1000 g, 1000-1500 g and >1500 g. Infants were randomised to either first receive HFNC flows 8-2 L/min and then nCPAP 6 cm H
resultsA total of 44 preterm infants, birth weights 500-1900 g, were studied. Increasing flows from 2 to 8 L/min significantly increased pEEP (mean 2.3-6.1 cm H
conclusionsHFNC therapy produces clinically significant pEEP with large variability at higher flow rates. Highest pressures were observed in infants weighing <1000 g. Flow, weight and mouth position are all important determinants of pressures generated. Reductions in pEECO
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.