Evidence map›Paper›PMID 31122994›Full record

ArticleBMJ open2019

Effects of brain training on brain blood flow (The Cognition and Flow Study-CogFlowS): protocol for a feasibility randomised controlled trial of cognitive training in dementia.

Lucy Beishon, Rachel Evley, Ronney B Panerai, Hari Subramaniam, Elizabeta Mukaetova-Ladinska, Thompson Robinson, Victoria Haunton

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03656107 (The Effects of Brain Training on Brain Blood Flow), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03656107 naterminatednot on this map

The Effects of Brain Training on Brain Blood Flow: The Cognition and Flow Study

TypeinterventionalSponsorUniversity of LeicesterRan2019 to 2020Enrolled56ConditionsDementia, Alzheimer Disease, Mild Cognitive Impairment, AgingArmsCognitive Training
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Lucy BeishonCardiovascular Sciences, University of Leicester College of Medicine Biological Sciences and Psychology, Leicester, UK.
Rachel EvleyDivision of Clinical Neuroscience, University of Nottingham, Nottingham, UK.
Ronney B PaneraiCardiovascular Sciences, University of Leicester College of Medicine Biological Sciences and Psychology, Leicester, UK.
Hari SubramaniamThe Evington Centre, Leicestershire Partnership NHSTrust, Leicester, UK.
Elizabeta Mukaetova-LadinskaDepartment of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK.
Thompson RobinsonCardiovascular Sciences, University of Leicester College of Medicine Biological Sciences and Psychology, Leicester, UK.
Victoria HauntonCardiovascular Sciences, University of Leicester College of Medicine Biological Sciences and Psychology, Leicester, UK.
Leicester College · GBBritish Heart Foundation · GBLeicestershire Partnership NHS Trust · GBNIHR Leicester Biomedical Research Centre · GBUniversity of Leicester · GBUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCognitive training is an emerging non-pharmacological treatment to improve cognitive and physical function in mild cognitive impairment (MCI) and early Alzheimer's disease (AD). Abnormal brain blood flow is a key process in the development of cognitive decline. However, no studies have explored the effects of cognitive training on brain blood flow in dementia. The primary aim of this study is to assess the feasibility for a large-scale, randomised controlled trial of cognitive training in healthy older adults (HC), MCI and early AD. METHODS AND ANALYSIS: This study will recruit 60 participants, in three subgroups of 20 (MCI, HC, AD), from primary, secondary and community services. Participants will be randomised to a 12-week computerised cognitive training programme (five × 30 min sessions per week), or waiting-list control. Participants will undergo baseline and follow-up assessments of: mood, cognition, quality of life and activities of daily living. Cerebral blood flow will be measured at rest and during task activation (pretraining and post-training) by bilateral transcranial Doppler ultrasonography, alongside heart rate (3-lead ECG), end-tidal CO ETHICS AND DISSEMINATION: Bradford Leeds Research Ethics committee awarded a favourable opinion (18/YH/0396). Results of the study will be published in peer-reviewed journals, and presented at national and international conferences on ageing and dementia. TRIALS REGISTRATION NUMBER: NCT03656107; Pre-results.

Indexed as

Activities of Daily LivingAffectAlzheimer DiseaseBrainCerebrovascular CirculationCognitionCognitive DysfunctionDementiaFeasibility StudiesFunctional NeuroimagingHumansQuality of LifeRandomized Controlled Trials as TopicSoftwareTherapy, Computer-AssistedUltrasonography, Doppler, Transcranialalzheimer’s diseasecerebral haemodynamicscognitive impairmentmild cognitive impairmentneuroimagingtranscranial doppler ultrasonography

Identifiers

PMID31122994
PMCPMC6538045
OpenAlexW2944841669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.