Evidence map›Paper›PMID 31122978›Full record

ArticleBMJ open2019

Performance of host blood transcriptomic signatures for diagnosing and predicting progression to tuberculosis disease in HIV-negative adults and adolescents: a systematic review protocol.

Humphrey Mulenga, Erick Wekesa Bunyasi, Stanley Kimbung Mbandi, Simon C Mendelsohn, Benjamin Kagina, Adam Penn-Nicholson, Thomas Scriba, Mark Hatherill

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Humphrey MulengaSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine and Department of Pathology, University of Cape Town, Faculty of Health Sciences, Cape Town, Western Cape, South Africa.ORCID 0000-0002-2030-0751
Erick Wekesa BunyasiSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine and Department of Pathology, University of Cape Town, Faculty of Health Sciences, Cape Town, Western Cape, South Africa.
Stanley Kimbung MbandiSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine and Department of Pathology, University of Cape Town, Faculty of Health Sciences, Cape Town, Western Cape, South Africa.ORCID 0000-0001-6121-9039
Simon C MendelsohnSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine and Department of Pathology, University of Cape Town, Faculty of Health Sciences, Cape Town, Western Cape, South Africa.
Benjamin KaginaVaccines For Africa (VACFA), University of Cape Town, Faculty of Health Sciences, Cape Town, Western Cape, South Africa.
Adam Penn-NicholsonSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine and Department of Pathology, University of Cape Town, Faculty of Health Sciences, Cape Town, Western Cape, South Africa.
Thomas Scriba *South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine and Department of Pathology, University of Cape Town, Faculty of Health Sciences, Cape Town, Western Cape, South Africa.
Mark Hatherill *South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine and Department of Pathology, University of Cape Town, Faculty of Health Sciences, Cape Town, Western Cape, South Africa.
University of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOne-quarter of the global population, including the majority of adults in tuberculosis (TB) endemic countries, are estimated to be METHODS AND ANALYSIS: This systematic review will involve conducting a comprehensive literature search of cohort, case-control, cross-sectional and randomised-controlled studies of the performance of host blood transcriptomic signatures for TB diagnosis and prediction of progression to TB disease. We will search Medline via PubMed, Scopus, Web of Science and EBSCO libraries, complemented by a search of bibliographies of selected articles for other relevant articles. The literature search will be restricted to studies published in English from 2005 to 2018 and conducted in HIV-uninfected adults and adolescents (≥12 years old). Forest plots and a narrative synthesis of the findings will be provided. The primary outcomes will be sensitivity, specificity, as well as true/false positives and true/false negatives. Heterogeneity resulting from differences in the design, composition and structure of individual signatures will preclude meta-analysis and pooling of results. ETHICS AND DISSEMINATION: Ethics approval is not required for this systematic review protocol. The results of this review will be disseminated through a peer-reviewed journal as well as conference presentations. PROSPERO REGISTRATION NUMBER: CRD42017073817.

Indexed as

Disease ProgressionTranscriptomeAdolescentAdultHIV SeronegativityHumansMycobacterium tuberculosisPrevalenceResearch DesignSystematic Reviews as TopicTuberculosissensitivity and specificitysignaturetranscriptomictuberculosis

Identifiers

PMID31122978
PMCPMC6538208
OpenAlexW2946028599

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.