ArticleEMBO molecular medicine2019
Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.
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Article in EMBO molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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75citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
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Who cites it
75 citing papers in PubMed, 136 citations in OpenAlex.
- Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice.Neurobiology of disease · 2026Article
- Activity-dependent protein synthesis in neurons requires microglial-metabolic coupling.Cell metabolism · 2026Article
- Immune dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2026Review
- Ferroptosis in microglial activation: a systematic review and multidata comparison.Brain communications · 2026Review
- The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks.Journal of neurochemistry · 2025Review
- Roles of TREM2 in Alzheimer's disease.Translational neurodegeneration · 2025Review
- Microglia coordinate activity-dependent protein synthesis in neurons through metabolic coupling.bioRxiv : the preprint server for biology · 2025Article
- Targeting Granulin Haploinsufficiency in Frontotemporal Dementia: From Genetic Mechanisms to Therapeutics.International journal of molecular sciences · 2025Review
- Ablation of progranulin augments microglial activation and accelerates prion progression.Acta neuropathologica communications · 2025Article
- Review
- Design, Synthesis and Preclinical Evaluation of a Brain-Permeable PET Tracer for P2Y12 Receptor Imaging in the Brain.Journal of medicinal chemistry · 2025Article
- The role of endolysosomal progranulin and TMEM106B in neurodegenerative diseases.Molecular neurodegeneration · 2025Review
- Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study.Translational psychiatry · 2025Article
- Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells.Translational neurodegeneration · 2025Review
- Human longevity and Alzheimer's disease variants act via microglia and oligodendrocyte gene networks.Brain : a journal of neurology · 2025Article
- Review
- TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis.Journal of neuroinflammation · 2025Article
- Small molecules as ligands in the tuning of immune regulatory receptors.Frontiers in immunology · 2025Review
- Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses.Aging and disease · 2024Review
- Analysis of intracellular communication reveals consistent gene changes associated with early-stage acne skin.Cell communication and signaling : CCS · 2024Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors at 7 institutions in 2 countries.
Julia K GötzlChair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
Matthias BrendelDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
Georg WernerChair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
Samira ParhizkarChair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
Laura Sebastian MonasorGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Gernot KleinbergerChair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID 0000-0002-5811-8226
Alessio-Vittorio ColomboGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Maximilian DeussingDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
Matias WagnerInstitut für Neurogenomik, Helmholtz Zentrum München, Munich, Germany.
Juliane WinkelmannInstitut für Neurogenomik, Helmholtz Zentrum München, Munich, Germany.
Janine Diehl-SchmidDepartment of Psychiatry, Technische Universität München, Munich, Germany.
Johannes LevinGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Katrin FellererChair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
Anika ReifschneiderChair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
Sebastian BultmannDepartment of Biology and Center for Integrated Protein Science Munich (CIPSM), Ludwig Maximilians-Universität München, Munich, Germany.
Peter BartensteinDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
Axel RomingerDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
Sabina TahirovicGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.ORCID 0000-0003-4403-9559
Scott T SmithAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Charlotte MadoreAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Oleg ButovskyAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Anja CapellChair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany anja.capell@mail03.med.uni-muenchen.de christian.haass@mail03.med.uni-muenchen.de.ORCID 0000-0003-3118-911X
Christian HaassChair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany anja.capell@mail03.med.uni-muenchen.de christian.haass@mail03.med.uni-muenchen.de.ORCID 0000-0002-4869-1627
Ludwig-Maximilians-Universität München · DEGerman Center for Neurodegenerative Diseases · DEBrigham and Women's Hospital · USMunich Cluster for Systems Neurology · DEHelmholtz Zentrum München · DECenter for Integrated Protein Science Munich · DETechnical University of Munich · DE
Funding
Targeting TGFb/IFNy-IRF8 Signaling to Modulate Monocytes and their Crosstalk with Microglia and Astrocytes to Treat Multiple SclerosisR01NS088137 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Oleg Butovsky · 2014 to 2026
$4.9MTargeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer’s diseaseR01AG054672 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BUTOVSKY, OLEG, IKEZU, TSUNEYA · 2017 to 2021
$4.1MMicroglial mechanisms of postoperative CNS inflammation and cognitive declineR01AG051812 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BUTOVSKY, OLEG, CROSBY, GREGORY · 2016 to 2020
$2.7MRole of Microglia in Retinitis PigementosaR01EY027921 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI BUTOVSKY, OLEG, HAIDER, NEENA B · 2017 to 2019
$1.5MIdentification of exosome signature in serum from ALS patientsR21NS104609 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI BERRY, JAMES DALE, BUTOVSKY, OLEG · 2018 to 2019
$543kIdentification of MicroRNA and Proteomics in immune cells and plasma in ALSR21NS101673 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI BERRY, JAMES DALE, BUTOVSKY, OLEG · 2017 to 2018
$504kNEI NIH HHS R01 EY027921NIA NIH HHS R01 AG051812NIA NIH HHS R01 AG054672NINDS NIH HHS R01 NS088137NINDS NIH HHS R21 NS101673NINDS NIH HHS R21 NS104609
Abstract
Microglia adopt numerous fates with homeostatic microglia (HM) and a microglial neurodegenerative phenotype (MGnD) representing two opposite ends. A number of variants in genes selectively expressed in microglia are associated with an increased risk for neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). Among these genes are progranulin (
Indexed as
CerebellumPositron-Emission TomographyAlzheimer DiseaseAnimalsFrontotemporal Lobar DegenerationGlucoseMembrane GlycoproteinsMiceMice, KnockoutMicrogliaProgranulinsReceptors, ImmunologicGlucoseGrn protein, mouseMembrane GlycoproteinsProgranulinsReceptors, ImmunologicTrem2 protein, mousedisease‐associated and homeostatic microglial signaturesmicroglianeurodegenerationprogranulinTREM2
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