Evidence map›Paper›PMID 31122895›Full record

ReviewThe Lancet. Respiratory medicine2019

Pragmatic methods to avoid intensive care unit admission when it does not align with patient and family goals.

Nita Khandelwal, Ann C Long, Robert Y Lee, Cara L McDermott, Ruth A Engelberg, J Randall Curtis

Abstract readReview
In one paragraph

Review in The Lancet. Respiratory medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Revue des maladies respiratoires actualites · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Delivery of end-of-life care in an emergency department-based intensive care unit.Journal of the American College of Emergency Physicians open · 2020
    Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Nita KhandelwalDepartment of Anesthesiology and Pain Medicine, University of Washington, Harborview Medical Center, Seattle, WA, USA; Cambia Palliative Care Center of Excellence, University of Washington, Harborview Medical Center, Seattle, WA, USA. Electronic address: khandel@uw.edu.
Ann C LongCambia Palliative Care Center of Excellence, University of Washington, Harborview Medical Center, Seattle, WA, USA; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Harborview Medical Center, Seattle, WA, USA.
Robert Y LeeCambia Palliative Care Center of Excellence, University of Washington, Harborview Medical Center, Seattle, WA, USA; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Harborview Medical Center, Seattle, WA, USA.
Cara L McDermottCambia Palliative Care Center of Excellence, University of Washington, Harborview Medical Center, Seattle, WA, USA; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Harborview Medical Center, Seattle, WA, USA.
Ruth A EngelbergCambia Palliative Care Center of Excellence, University of Washington, Harborview Medical Center, Seattle, WA, USA; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Harborview Medical Center, Seattle, WA, USA.
J Randall CurtisCambia Palliative Care Center of Excellence, University of Washington, Harborview Medical Center, Seattle, WA, USA; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Harborview Medical Center, Seattle, WA, USA.

Funding

Palliative Care Research Training GrantT32HL125195 · NHLBI · UNIVERSITY OF WASHINGTON · PI KROSS, ERIN KATHRYN, SHARMA, RASHMI K. · 2015 to 2024
$3.2M
University of Washington Implementation Science Training Program (UW-ISTP)K12K12HL137940 · NHLBI · UNIVERSITY OF WASHINGTON · PI AU, DAVID H, CURTIS, J RANDALL · 2017 to 2021
$2.9M
Improving clinical outcomes after ICU transfer for acute respiratory failureK23HL128793 · NHLBI · UNIVERSITY OF WASHINGTON · PI JENNERICH, ANN LONG · 2017 to 2021
$941k
Goal-discordant care in acute respiratory failure: risk factors and mechanismsF32HL142211 · NHLBI · UNIVERSITY OF WASHINGTON · PI LEE, ROBERT YING-FU · 2018 to 2019
$99k
NHLBI NIH HHS F32 HL142211NHLBI NIH HHS K12 HL137940NHLBI NIH HHS K23 HL128793NHLBI NIH HHS T32 HL125195
6 · The paper itself

Abstract

For patients with chronic, life-limiting illnesses, admission to the intensive care unit (ICU) near the end of life might not improve patient outcomes or be consistent with patient and family values, goals, and preferences. In this context, advance care planning and palliative care interventions designed to clarify patients' values, goals, and preferences have the potential to reduce provision of high-intensity interventions that are unwanted or non-beneficial. In this Series paper, we have assessed interventions that are effective at helping patients with chronic, life-limiting illnesses to avoid an unwanted ICU admission. The evidence found was largely from observational studies, with considerable heterogeneity in populations, methods, and types of interventions. Results from randomised trials of interventions to improve communication about goals of care are scarce, of variable quality, and mixed. Although observational studies show that advance care planning and palliative care interventions are associated with a reduced number of ICU admissions at the end of life, causality has not been well established. Using the available evidence we suggest recommendations to help to avoid ICU admission when it does not align with patient and family values, goals, and preferences and conclude with future directions for research.

Indexed as

Critical CareGoalsHospitalizationPalliative CarePatient PreferenceTerminal CareHumans

Identifiers

PMID31122895
PMCPMC6733408

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.