Evidence map›Paper›PMID 31122794›Full record

ArticleAmerican journal of preventive medicine2019

Association of Fitness With Racial Differences in Chronic Kidney Disease.

Amanda E Paluch, Lindsay R Pool, Tamara Isakova, Cora E Lewis, Rupal Mehta, Pamela J Schreiner, Stephen Sidney, Myles Wolf, Mercedes R Carnethon

Open access · greenAbstract read
In one paragraph

Article in American journal of preventive medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Amanda E PaluchDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address: amanda.paluch@northwestern.edu.
Lindsay R PoolDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Tamara IsakovaCenter for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Cora E LewisDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama.
Rupal MehtaCenter for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Pamela J SchreinerDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota.
Stephen SidneyDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Myles WolfDivision of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina; Duke Clinical Research Institute, Durham, North Carolina.
Mercedes R CarnethonDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Northwestern University · USClinical Research Institute · USKaiser Permanente · USUniversity of Alabama at Birmingham · USUniversity of Minnesota · US

Funding

Research Design, Data, and Analytics CoreP30DK092949 · NIDDK · UNIVERSITY OF CHICAGO · PI ELBERT S. HUANG · 2011 to 2026
$10.0M
20 YEAR CHANGES IN FITNESS &CARDIOVASCULAR DISEASE RISKR01HL078972 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI SIDNEY, STEPHEN · 2005 to 2008
$6.1M
NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS R01 HL078972NIDDK NIH HHS P30 DK092949
6 · The paper itself

Abstract

introductionNon-white minorities are at higher risk for chronic kidney disease than non-Hispanic whites. Better cardiorespiratory fitness is associated with slower declines in estimated glomerular filtration rate and a lower incidence of chronic kidney disease. Little is known regarding associations of fitness with racial disparities in chronic kidney disease.

methodsA prospective cohort of 3,842 young adults without chronic kidney disease completed a maximal treadmill test at baseline in 1985-1986. Chronic kidney disease status was defined as estimated glomerular filtration rate of <60 mL/min/1.73 m

resultsChronic kidney disease incidence was higher among blacks (n=83/1,941, 1.61 per 1,000 person years) than whites (43/1,901, 0.82 per 1,000 person years). Every 1-minute shorter treadmill duration was associated with 1.14 (95% CI=1.04, 1.25) times higher risk of chronic kidney disease. Blacks were 1.72 (95% CI=1.13, 2.63) times more likely to develop chronic kidney disease compared with whites. The risk was reduced to 1.54 (95% CI=1.01, 2.39) with fitness added. This suggests that fitness is associated with 20.4% (95% CI=5.8, 43.0%) of the excess risk of chronic kidney disease attributable to race.

conclusionsLow fitness is a modifiable factor that may contribute to the racial disparity in chronic kidney disease.

Indexed as

AdultBlack or African AmericanBlood PressureCardiorespiratory FitnessFemaleGlomerular Filtration RateHumansIncidenceLongitudinal StudiesMaleMiddle AgedProspective StudiesRenal Insufficiency, ChronicWhite PeopleYoung Adult

Identifiers

PMID31122794
PMCPMC6589135
OpenAlexW2946225104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.