ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2019
Evaluation of a 16-week Change Cycle for Ventilated Mouse Cages.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed.
- Maintaining Welfare While Extending Cage-Change Intervals: A Performance-Based Study in IVC-Housed Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Using Machine Learning and Predictive Artificial Intelligence to Determine Cage Change Frequency for Mice Housed in Individually Ventilated Cages and Drive Vivarium Operational Efficiency.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Analysis of Individually Ventilated Cage (IVC) Microenvironments During 21-d Cage Change Frequency for Mice Using Two Different Bedding Types.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Longitudinal Study of Changes in Ammonia, Carbon Dioxide, Humidity and Temperature in Individually Ventilated Cages Housing Female and Male C57BL/6N Mice during Consecutive Cycles of Weekly and Bi-Weekly Cage Changes.Animals : an open access journal from MDPI · 2024Article
- Evaluation and Refinement of a Spot-change-only Cage Management System for Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Article
- Assessing Accumulation of Organic Material on Rodent Cage Accessories.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The methods and conditions for housing research mice have been the subject of many discussions and publications in recent years. At our institution, we began to explore these matters with the goal of reducing stress in the animals and yet maintaining an environment that more closely resembled their habitat in the wild and yet was acceptable to researchers and the technicians that cared for the animals. Through a series of small inhouse studies, we derived a method that allowed the animals to stay in their established environment for longer than the standard 1- or 2-wk period. After several empirical studies, we concluded that the mice could stay in the same cage for 16 wk or perhaps even longer. To achieve this outcome, we perfected a method of removing 75% of the existing cage bedding and replacing it with clean bedding every 2 wk. To substantiate the validity of the method, we conducted a major study that evaluated the conditions of the cage, cage environment and the animals for a 16-wk period. In the study, we compared all of these factors in the 16-wk cages to a set of cages that were completely replaced on a 2-wk cycle. The mice in our study appeared to experience decreased stress, and observation also revealed that the 16-wk method was associated with increased pup survival in several colonies. The revised 16-wk method appears to create mouse cage conditions that are no different than the current standard (that is, every 1 or 2 wk) methods of cage changing.
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