Evidence map›Paper›PMID 31122309›Full record

ArticleJournal of the International Neuropsychological Society : JINS2019

Neuropsychological Test Norms in Cognitively Intact Oldest-Old.

Zarui A Melikyan, Maria M Corrada, Malcolm B Dick, Christina Whittle, Annlia Paganini-Hill, Claudia H Kawas

Abstract read
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cerebral perfusion and amyloidosis in the oldest-old.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  6. Article
  7. Resilience to AD pathology in Top Cognitive Performers.Frontiers in aging neuroscience · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Naming in Older Adults: Complementary Auditory and Visual Assessment.Journal of the International Neuropsychological Society : JINS · 2022
    Article
  14. Article
  15. Norms and equivalences for MoCA-30, MoCA-22, and MMSE in the oldest-old.Aging clinical and experimental research · 2021
    Article
  16. Diagnosis and Management of Cognitive Concerns in the Oldest-Old.Current treatment options in neurology · 2021
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zarui A Melikyan1Institute for Memory Impairments and Neurological Disorders,University of California,Irvine,California.ORCID 0000-0002-8495-5546
Maria M Corrada1Institute for Memory Impairments and Neurological Disorders,University of California,Irvine,California.
Malcolm B Dick1Institute for Memory Impairments and Neurological Disorders,University of California,Irvine,California.
Christina Whittle1Institute for Memory Impairments and Neurological Disorders,University of California,Irvine,California.
Annlia Paganini-Hill2Department of Neurology,University of California,Irvine,California.
Claudia H Kawas1Institute for Memory Impairments and Neurological Disorders,University of California,Irvine,California.

Funding

UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
Diversity Supplement to R01AG021055; Clinical, Imaging, and Pathological Studies in the Oldest Old: The 90+ StudyR01AG021055 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CORRADA, MARIA, KAWAS, CLAUDIA H. · 2002 to 2024
$36.9M
NIA NIH HHS P50 AG016573NIA NIH HHS R01 AG021055
6 · The paper itself

Abstract

objectivesIndividuals aged 90 or older (oldest-old), the fastest growing segment of the population, are at increased risk of developing cognitive impairment compared with younger old. Neuropsychological evaluation of the oldest-old is important yet challenging in part because of the scarcity of test norms for this group. We provide neuropsychological test norms for cognitively intact oldest-old.

methodsTest norms were derived from 403 cognitively intact participants of The 90+ Study, an ongoing study of aging and dementia in the oldest-old. Cognitive status of intact oldest-old was determined at baseline using cross-sectional approach. Individuals with cognitive impairment no dementia or dementia (according to DSM-IV criteria) were excluded. Participants ranged in age from 90 to 102 years (mean=94). The neuropsychological battery included 11 tests (Mini-Mental Status Examination, Modified Mini-Mental State Examination, Boston Naming Test - Short Form, Letter Fluency Test, Animal Fluency Test, California Verbal Learning Test-II Short Form, Trail Making Tests A/B/C, Digit Span Forward and Backwards Test, Clock Drawing Test, CERAD Construction Subtests), and the Geriatric Depression Scale.

resultsData show significantly lower scores with increasing age on most tests. Education level, sex, and symptoms of depression were associated with performance on several tests after accounting for age.

conclusionsProvided test norms will help to distinguish cognitively intact oldest-old from those with cognitive impairment. (JINS, 2019, 25, 530-545).

Indexed as

Aged, 80 and overAgingCognitionCross-Sectional StudiesFemaleHumansMaleMemory and Learning TestsMental Status and Dementia TestsNeuropsychological TestsReference ValuesTrail Making Test80 and overAgedCognitionGeriatric assessmentNeuropsychologyReference values

Identifiers

PMID31122309
PMCPMC6538395

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.