ArticleClinical epigenetics2019
Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus.
Article in Clinical epigenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 86 citations in OpenAlex.
- Effects of improved on-farm crop storage on DNA methylation of mothers and their infants: evidence from a randomized controlled trial in Kenya.Clinical epigenetics · 2024Trial
- The aging paradox of Cushing's syndrome: Stress without clear senescence?Journal of neuroendocrinology · 2026Review
- Review
- Steroid hormone-mediated epigenetic programming during puberty: uncovering links to depression.Epigenomics · 2025Review
- NR3C1-mediated epigenetic regulation suppresses astrocytic immune responses in mice.Nature communications · 2025Article
- Early-Life Adversity and Epigenetic Aging: Findings from a 17-Year Longitudinal Study.Biomolecules · 2025Article
- Cell-Derived Epigenomic Markers of Chronic Stress Distinguish Breast Cancer Phenotypes.The Yale journal of biology and medicine · 2025Article
- BDNF methylation associated with stress in women: Novel insights in epigenetics and inflammation.Brain, behavior, & immunity - health · 2024Article
- Prenatal exposures and cell type proportions are main drivers ofNeurobiology of stress · 2024Article
- Epigenetic associations in HPA axis genes related to bronchopulmonary dysplasia and antenatal steroids.Pediatric research · 2024Article
- The role of resilience in the relationship between stress and alcohol.Neurobiology of stress · 2024Article
- DNA methylation patterns of FKBP5 regulatory regions in brain and blood of humanized mice and humans.Molecular psychiatry · 2024Article
- Mitochondrial Transplantation's Role in Rodent Skeletal Muscle Bioenergetics: Recharging the Engine of Aging.Biomolecules · 2024Article
- HPA flexibility andPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Glucocorticoid effects on the brain: from adaptive developmental plasticity to allostatic overload.The Journal of experimental biology · 2024Review
- Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness.Clinical epigenetics · 2024Article
- Methylation Patterns of the FKBP5 Gene in Association with Childhood Maltreatment and Depressive Disorders.International journal of molecular sciences · 2024Article
- The HPA Axis as Target for Depression.Current neuropharmacology · 2024Article
- Genome-wide DNA methylation analysis implicates enrichment of interferon pathway in African American patients with Systemic Lupus Erythematosus and European Americans with lupus nephritis.Journal of autoimmunity · 2023Article
- Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex.Acta neuropathologica · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundEpigenetic mechanisms may play a major role in the biological embedding of early-life stress (ELS). One proposed mechanism is that glucocorticoid (GC) release following ELS exposure induces long-lasting alterations in DNA methylation (DNAm) of important regulatory genes of the stress response. Here, we investigate the dynamics of GC-dependent methylation changes in key regulatory regions of the FKBP5 locus in which ELS-associated DNAm changes have been reported.
resultsWe repeatedly measured DNAm in human peripheral blood samples from 2 independent cohorts exposed to the GC agonist dexamethasone (DEX) using a targeted bisulfite sequencing approach, complemented by data from Illumina 450K arrays. We detected differentially methylated CpGs in enhancers co-localizing with GC receptor binding sites after acute DEX treatment (1 h, 3 h, 6 h), which returned to baseline levels within 23 h. These changes withstood correction for immune cell count differences. While we observed main effects of sex, age, body mass index, smoking, and depression symptoms on FKBP5 methylation levels, only the functional FKBP5 SNP (rs1360780) moderated the dynamic changes following DEX. This genotype effect was observed in both cohorts and included sites previously shown to be associated with ELS.
conclusionOur study highlights that DNAm levels within regulatory regions of the FKBP5 locus show dynamic changes following a GC challenge and suggest that factors influencing the dynamics of this regulation may contribute to the previously reported alterations in DNAm associated with current and past ELS exposure.
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