Evidence map›Paper›PMID 31122267›Full record

ArticleAlzheimer's research & therapy2019

Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer's disease: protocol of the BEAT-IT study.

Willem S Eikelboom, Ellen Singleton, Esther van den Berg, Michiel Coesmans, Francesco Mattace Raso, Rozemarijn L van Bruchem, Jeannette A Goudzwaard, Frank Jan de Jong, Marc Koopmanschap, Tom den Heijer and 11 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  12. Task switching reveals abnormal brain-heart electrophysiological signatures in cognitively healthy individuals with abnormal CSF amyloid/tau, a pilot study.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2021
    Article
  13. Pharmacological Mechanisms Underlying the Neuroprotective Effects ofInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Willem S EikelboomDepartment of Neurology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands.
Ellen SingletonDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands.
Esther van den BergDepartment of Neurology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands.
Michiel CoesmansDepartment of Psychiatry, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands.
Francesco Mattace RasoDepartment of Internal Medicine, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands.
Rozemarijn L van BruchemDepartment of Internal Medicine, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands.
Jeannette A GoudzwaardDepartment of Internal Medicine, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands.
Frank Jan de JongDepartment of Neurology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands.
Marc KoopmanschapErasmus School of Health Policy & Management, Erasmus University, PO Box 1738, 3000 DR, Rotterdam, the Netherlands.
Tom den HeijerDepartment of Neurology, Franciscus Gasthuis, PO Box 10900, 3004 BA, Rotterdam, the Netherlands.
Jan J M DriesenDepartment of Neurology, Franciscus Vlietland, PO Box 215, 3100 AE, Schiedam, the Netherlands.
Lilian J H M VroegindeweijDepartment of Neurology, Het Van Weel-Bethesda Ziekenhuis, PO Box 153, 3240 AD, Dirksland, the Netherlands.
Elsbeth C ThomeerDepartment of Neurology, Maasstad Hospital, PO Box 9100, 3007 AC, Rotterdam, the Netherlands.
Susanne E HoogersDepartment of Neurology, Spijkenisse Medical Center, PO Box 777, 3200 GA, Spijkenisse, the Netherlands.
Anke A DijkstraDepartment of Anatomy and Neurosciences, Amsterdam University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands.
Sytse U ZuidemaDepartment of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, PO Box 30,001, 9700 RB, Groningen, the Netherlands.
Yolande A L PijnenburgDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands.
Philip ScheltensDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands.
John C van SwietenDepartment of Neurology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands.
Rik OssenkoppeleDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands.
Janne M PapmaDepartment of Neurology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands. j.papma@erasmusmc.nl.

Funding

Alzheimer Nederland (NL) and Memorabel ZonMw (NL) 733050823
6 · The paper itself

Abstract

backgroundNeuropsychiatric symptoms (NPS) are very common in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia and are associated with various disadvantageous clinical outcomes including a negative impact on quality of life, caregiver burden, and accelerated disease progression. Despite growing evidence of the efficacy of (non)pharmacological interventions to reduce these symptoms, NPS remain underrecognized and undertreated in memory clinics. The BEhavioural symptoms in Alzheimer's disease Towards early Identification and Treatment (BEAT-IT) study is developed to (1) investigate the neurobiological etiology of NPS in AD and (2) study the effectiveness of the Describe, Investigate, Create, Evaluate (DICE) approach to structure and standardize the current care of NPS in AD. By means of the DICE method, we aim to improve the quality of life of AD patients with NPS and their caregivers who visit the memory clinic. This paper describes the protocol for the intervention study that incorporates the latter aim.

methodsWe aim to enroll a total of 150 community-dwelling patients with MCI or AD and their caregivers in two waves. First, we will recruit a control group who will receive care as usual. Next, the second wave of participants will undergo the DICE method. This approach consists of the following steps: (1) describe the context in which NPS occur, (2) investigate the possible causes, (3) create and implement a treatment plan, and (4) evaluate whether these interventions are effective. Primary outcomes are the quality of life of patients and their caregivers. Secondary outcomes include NPS change, caregiver burden, caregivers' confidence managing NPS, psychotropic medication use, the experiences of patients and caregivers who underwent the DICE method, and the cost-effectiveness of the intervention.

conclusionsThis paper describes the protocol of an intervention study that is part of the BEAT-IT study and aims to improve current recognition and treatment of NPS in AD by structuring and standardizing the detection and treatment of NPS in AD using the DICE approach.

trial registrationThe trial was registered on the Netherlands Trial Registry ( NTR7459 ); registered 6 September 2018.

Indexed as

Alzheimer DiseaseBehavioral SymptomsCognitive DysfunctionPsychological DistressQuality of LifeControlled Clinical Trials as TopicCost-Benefit AnalysisFollow-Up StudiesHumansMulticenter Studies as TopicNeuropsychological TestsOutcome Assessment, Health CarePsychiatric Status Rating ScalesResearch DesignAlzheimer’s diseaseBehaviorCaregiversCost-benefit analysisDementiaNeuropsychiatryProspective studiesQuality of life

Identifiers

PMID31122267
PMCPMC6533693

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.