ArticleLipids in health and disease2019
Statin therapy is associated with improved survival in patients with ventricular tachyarrhythmias.
Article in Lipids in health and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02982473 (Registry of Malignant Arrhythmias and Sudden Cardiac Death - Influence of Diagnostics and Interventions), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Registry of Malignant Arrhythmias and Sudden Cardiac Death - Influence of Diagnostics and Interventions
Who cites it
6 citing papers in PubMed.
- Impact of Hospital Volume on In-Hospital Cardiac Arrest Mortality: Trends Before and During the COVID-19 Pandemic.Cureus · 2025Article
- Characteristics Associated with Ventricular Tachyarrhythmias and Their Prognostic Impact in Heart Failure with Mildly Reduced Ejection Fraction.Journal of clinical medicine · 2024Article
- Effect of Cardiovascular Risk Factors on 30-Day All-Cause Mortality in Cardiogenic Shock.Journal of clinical medicine · 2023Article
- Effect of Statins on All-Cause Mortality in Adults: A Systematic Review and Meta-Analysis of Propensity Score-Matched Studies.Journal of clinical medicine · 2022Review
- Mechanisms Underlying Antiarrhythmic Properties of Cardioprotective Agents Impacting Inflammation and Oxidative Stress.International journal of molecular sciences · 2022Review
- Consistent use of lipid lowering therapy in HIV infection is associated with low mortality.BMC infectious diseases · 2021Article
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe study sought to assess the impact of statin therapy on survival in patients presenting with ventricular tachyarrhythmias.
backgroundData regarding the outcome of patients with statin therapy presenting with ventricular tachyarrhythmias is limited.
methodsA large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) or fibrillation (VF) from 2002 to 2016. Patients with statin were compared to patients without statin therapy (non-statin). The primary prognostic endpoint was long-term all-cause death at 3 years. Uni- and multivariable Cox regression analyses were applied in propensity-score matched cohorts.
resultsA total of 424 matched patients was included. The rates of VT and VF were similar in both groups (VT: statin 71% vs. non-statin 68%; VF: statin 29% vs. 32%; p = 0.460). Statin therapy was associated with lower all-cause mortality at long-term follow-up (mortality rates 16% versus 33%; log rank, p = 0.001; HR = 0.438; 95% CI 0.290-0.663; p = 0.001), irrespective of the underlying type of ventricular tachyarrhythmia (VT/VF), left ventricular ejection fraction (LVEF) > 35%, presence of an activated implantable cardioverter defibrillator (ICD), cardiogenic shock or cardiopulmonary resuscitation (CPR).
conclusionStatin therapy is independently associated with lower long-term mortality in patients presenting with ventricular tachyarrhythmias on admission.
trial registrationClinicaltrials.gov, NCT02982473 , 11/29/2016, Retrospectively registered.
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